DEPICTER: intrinsic disorder and disorder function prediction server.
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Author(s)
Barik, Amita
Katuwawala, Akila
Hanson, Jack
Paliwal, Kuldip
Zhou, Yaoqi
Kurgan, Lukasz
Griffith University Author(s)
Year published
2020
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Show full item recordAbstract
Computational predictions of the intrinsic disorder and its functions are instrumental to facilitate annotation for the millions of unannotated proteins. However, access to these predictors is fragmented and requires substantial effort to find them and to collect and combine their results. The DEPICTER (DisorderEd PredictIon CenTER) server provides first-of-its-kind centralized access to ten popular disorder and disorder function predictions that cover protein and nucleic acids binding, linkers and moonlighting regions. It automates the prediction process, runs user-selected methods on the server side, visualizes the results, ...
View more >Computational predictions of the intrinsic disorder and its functions are instrumental to facilitate annotation for the millions of unannotated proteins. However, access to these predictors is fragmented and requires substantial effort to find them and to collect and combine their results. The DEPICTER (DisorderEd PredictIon CenTER) server provides first-of-its-kind centralized access to ten popular disorder and disorder function predictions that cover protein and nucleic acids binding, linkers and moonlighting regions. It automates the prediction process, runs user-selected methods on the server side, visualizes the results, and outputs all predictions in a consistent and easy to parse format. DEPICTER also includes two accurate consensus predictors of disorder and disordered protein-binding. Empirical tests on an independent (low similarity) benchmark dataset reveal that the computational tools included in DEPICTER generate accurate predictions that are significantly better than the results secured using sequence alignment. The DEPICTER server is freely available at http://biomine.cs.vcu.edu/servers/DEPICTER/.
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View more >Computational predictions of the intrinsic disorder and its functions are instrumental to facilitate annotation for the millions of unannotated proteins. However, access to these predictors is fragmented and requires substantial effort to find them and to collect and combine their results. The DEPICTER (DisorderEd PredictIon CenTER) server provides first-of-its-kind centralized access to ten popular disorder and disorder function predictions that cover protein and nucleic acids binding, linkers and moonlighting regions. It automates the prediction process, runs user-selected methods on the server side, visualizes the results, and outputs all predictions in a consistent and easy to parse format. DEPICTER also includes two accurate consensus predictors of disorder and disordered protein-binding. Empirical tests on an independent (low similarity) benchmark dataset reveal that the computational tools included in DEPICTER generate accurate predictions that are significantly better than the results secured using sequence alignment. The DEPICTER server is freely available at http://biomine.cs.vcu.edu/servers/DEPICTER/.
View less >
Journal Title
Journal of Molecular Biology
Funder(s)
ARC
Grant identifier(s)
DP180102060
Copyright Statement
© 2019 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
Subject
Medicinal and biomolecular chemistry
Biochemistry and cell biology
Microbiology
Webserver
intrinsically disordered proteins
intrinsically disordered region
prediction center
protein-nucleic acids interactions