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dc.contributor.authorBlacksell, Stuart D
dc.contributor.authorRobinson, Matthew T
dc.contributor.authorNewton, Paul N
dc.contributor.authorRuanchaimun, Soiratchaneekorn
dc.contributor.authorSalje, Jeanne
dc.contributor.authorWangrangsimakul, Tri
dc.contributor.authorWegner, Matthew D
dc.contributor.authorAbdad, Mohammad Yazid
dc.contributor.authorBennett, Allan M
dc.contributor.authorRichards, Allen L
dc.contributor.authorStenos, John
dc.contributor.authorDay, Nicholas PJ
dc.date.accessioned2020-01-17T04:53:23Z
dc.date.available2020-01-17T04:53:23Z
dc.date.issued2019
dc.identifier.issn1471-2334
dc.identifier.doi10.1186/s12879-019-4653-4
dc.identifier.urihttp://hdl.handle.net/10072/390591
dc.description.abstractScrub typhus is an important arthropod-borne disease causing significant acute febrile illness by infection with Orientia spp.Using a risk-based approach, this review examines current practice, the evidence base and regulatory requirements regarding matters of biosafety and biosecurity, and presents the case for reclassification from Risk Group 3 to Risk Group 2 along with recommendations for safe working practices of risk-based activities during the manipulation of Orientia spp. in the laboratory.We recommend to reclassify Orientia spp. to Risk Group 2 based on the classification for RG2 pathogens as being moderate individual risk, low community risk. We recommend that low risk activities, can be performed within a biological safety cabinet located in a Biosafety Level (BSL) 2 core laboratory using standard personal protective equipment. But when the risk assessment indicates, such as high concentration and volume, or aerosol generation, then a higher biocontainment level is warranted. For, the majority of animal activities involving Orientia spp., Animal BSL 2 (ABSL2) is recommended however where high risk activities are performed including necropsies, Animal BSL (ABSL3) is recommended.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central Ltd.
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom1044:1
dc.relation.ispartofpageto1044:10
dc.relation.ispartofissue1
dc.relation.ispartofjournalBMC Infectious Diseases
dc.relation.ispartofvolume19
dc.subject.fieldofresearchMedical Microbiology
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode1108
dc.subject.fieldofresearchcode0605
dc.subject.fieldofresearchcode1103
dc.subject.keywordsBiocontainment
dc.subject.keywordsBiosafety
dc.subject.keywordsOrientia
dc.subject.keywordsRisk group
dc.subject.keywordsScrub typhus
dc.titleBiosafety and biosecurity requirements for Orientia spp. diagnosis and research: recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBlacksell, SD; Robinson, MT; Newton, PN; Ruanchaimun, S; Salje, J; Wangrangsimakul, T; Wegner, MD; Abdad, MY; Bennett, AM; Richards, AL; Stenos, J; Day, NPJ, Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2., BMC Infectious Diseases, 2019, 19 (1), pp. 1044:1-1044:10
dcterms.dateAccepted2019-11-22
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-01-17T04:44:44Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
gro.hasfulltextFull Text
gro.griffith.authorStenos, John


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