Show simple item record

dc.contributor.authorYoulden, Danny R
dc.contributor.authorBaade, Peter D
dc.contributor.authorWalker, Rick
dc.contributor.authorPyke, Christopher M
dc.contributor.authorRoder, David M
dc.contributor.authorAitken, Joanne F
dc.date.accessioned2022-03-23T01:44:23Z
dc.date.available2022-03-23T01:44:23Z
dc.date.issued2019
dc.identifier.issn2156-5333
dc.identifier.doi10.1089/jayao.2019.0119
dc.identifier.urihttp://hdl.handle.net/10072/390592
dc.description.abstractPurpose: Breast cancer is the most common cancer diagnosed among adolescent and young adult (AYA) females worldwide, but epidemiological patterns unique to this group are often obscured when results are combined with older patients. This study investigates breast cancer incidence and survival among AYA females, including differences by broad stage at diagnosis. Methods: A retrospective, population-based cohort study was conducted using de-identified data for females in Queensland, Australia, aged 15–39 diagnosed with a first primary breast cancer between 1997 and 2014 with follow-up to December 31, 2016. Incidence rate trends were examined with Joinpoint analysis. Cause-specific survival was calculated for key characteristics, and 5-year adjusted hazard ratios (HRs) were estimated from a multivariable flexible parametric model. Results: The study cohort comprised 2337 patients, of whom two-thirds (n = 1565, 67%) were diagnosed with advanced disease (tumor diameter >20 mm, lymph node involvement or presence of distant metastases at diagnosis). Incidence rates of localized tumors decreased by 1.9% per year (95% confidence interval [CI] −3.5% to −0.4%) over the study period, whereas the trend for advanced breast cancers remained stable. Five-year cause-specific survival increased from 85% to 92% for 2011–2014 compared to 1997–2001 (adjusted HR = 0.43, 95% CI = 0.29–0.65). Patients who were Indigenous from disadvantaged areas or diagnosed with advanced stage experienced significantly worse survival. Conclusion: The high proportion of younger females diagnosed with advanced breast cancer should be the focus of future campaigns to improve awareness and earlier detection. While survival has increased over time, further work is required to ensure that this progress is experienced equitably by all patients.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMary Ann Liebert
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom402
dc.relation.ispartofpageto409
dc.relation.ispartofissue3
dc.relation.ispartofjournalJournal of Adolescent and Young Adult Oncology
dc.relation.ispartofvolume9
dc.subject.fieldofresearchNursing
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode4205
dc.subject.fieldofresearchcode3211
dc.subject.keywordsincidence
dc.subject.keywordssurvival
dc.subject.keywordsQueensland
dc.subject.keywordsWOMEN
dc.subject.keywordsTRENDS
dc.titleBreast Cancer Incidence and Survival Among Young Females in Queensland, Australia
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationYoulden, DR; Baade, PD; Walker, R; Pyke, CM; Roder, DM; Aitken, JF, Breast Cancer Incidence and Survival Among Young Females in Queensland, Australia, Journal of Adolescent and Young Adult Oncology, 2020, 9 (3), pp. 402-409
dc.date.updated2020-01-17T04:49:14Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyrightThis is a copy of an article published in the Journal of Adolescent and Young Adult Oncology. Copyright 2020 Mary Ann Liebert, Inc. Final publication is available from Mary Ann Liebert, Inc., publishers https://doi.org/10.1089/jayao.2019.0119
gro.hasfulltextFull Text
gro.griffith.authorBaade, Peter D.
gro.griffith.authorYoulden, Danny R.
gro.griffith.authorAitken, Joanne


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record