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  • Mitochondria break through cellular boundaries (Editorial)

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    Neuzil233905Published.pdf (224.7Kb)
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    Author(s)
    Neuzil, Jiri
    Berridge, Michael V
    Griffith University Author(s)
    Neuzil, Jiri
    Year published
    2019
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    Abstract
    In our recent research, we have used respiration-deficient tumour cells to challenge the dogma that mitochondria with their genome are constrained within cells in the body, and to question the concept that mitochondria are primarily the powerhouse of the cell. Our results have shown that mitochondria move from normal cells in the body to tumour cells without mitochondrial DNA (mtDNA), resulting in respiration recovery and the ability to grow as tumours [1, 2]. Almost a decade earlier, a similar phenomenon had been show in co-cultures of human tumour cells lacking mtDNA with mesenchymal stem cells [3]. The strength of both ...
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    In our recent research, we have used respiration-deficient tumour cells to challenge the dogma that mitochondria with their genome are constrained within cells in the body, and to question the concept that mitochondria are primarily the powerhouse of the cell. Our results have shown that mitochondria move from normal cells in the body to tumour cells without mitochondrial DNA (mtDNA), resulting in respiration recovery and the ability to grow as tumours [1, 2]. Almost a decade earlier, a similar phenomenon had been show in co-cultures of human tumour cells lacking mtDNA with mesenchymal stem cells [3]. The strength of both of these ground-breaking studies was that they used mtDNA polymorphisms to show repopulation of tumour cells with mtDNA, establishing the origin of mitochondria in the donor cells.
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    Journal Title
    Aging-US
    Volume
    11
    Issue
    13
    DOI
    https://doi.org/10.18632/aging.102103
    Copyright Statement
    © The Author(s) 2019. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Biochemistry and cell biology
    Zoology
    Oncology and carcinogenesis
    Science & Technology
    Life Sciences & Biomedicine
    Cell Biology
    Geriatrics & Gerontology
    mitochondrial transfer
    Publication URI
    http://hdl.handle.net/10072/390635
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    • Journal articles

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