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dc.contributor.authorSweetman, Eiren
dc.contributor.authorNoble, Alex
dc.contributor.authorEdgar, Christina
dc.contributor.authorMackay, Angus
dc.contributor.authorHelliwell, Amber
dc.contributor.authorVallings, Rosamund
dc.contributor.authorRyan, Margaret
dc.contributor.authorTate, Warren
dc.date.accessioned2020-01-22T03:18:26Z
dc.date.available2020-01-22T03:18:26Z
dc.date.issued2019
dc.identifier.issn2075-4418
dc.identifier.doi10.3390/diagnostics9030073
dc.identifier.urihttp://hdl.handle.net/10072/390722
dc.description.abstractMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe fatigue illness that occurs most commonly following a viral infection, but other physiological triggers are also implicated. It has a profound long-term impact on the life of the affected person. ME/CFS is diagnosed primarily by the exclusion of other fatigue illnesses, but the availability of multiple case definitions for ME/CFS has complicated diagnosis for clinicians. There has been ongoing controversy over the nature of ME/CFS, but a recent detailed report from the Institute of Medicine (Academy of Sciences, USA) concluded that ME/CFS is a medical, not psychiatric illness. Importantly, aspects of the biological basis of the ongoing disease have been revealed over the last 2-3 years that promise new leads towards an effective clinical diagnostic test that may have a general application. Our detailed molecular studies with a preclinical study of ME/CFS patients, along with the complementary research of others, have reported an elevation of inflammatory and immune processes, ongoing neuro-inflammation, and decreases in general metabolism and mitochondrial function for energy production in ME/CFS, which contribute to the ongoing remitting/relapsing etiology of the illness. These biological changes have generated potential molecular biomarkers for use in diagnostic ME/CFS testing.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMDPI
dc.publisher.placeSwitzerland
dc.relation.ispartofpagefrom73: 1
dc.relation.ispartofpageto73: 14
dc.relation.ispartofissue3
dc.relation.ispartofjournalDiagnostics
dc.relation.ispartofvolume9
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode1103
dc.subject.keywordschronic fatigue syndrome
dc.subject.keywordscircadian rhythm
dc.subject.keywordsdiagnostic biomarker
dc.subject.keywordsinflammation and immunity
dc.subject.keywordsmetabolism
dc.titleCurrent Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSweetman, E; Noble, A; Edgar, C; Mackay, A; Helliwell, A; Vallings, R; Ryan, M; Tate, W, Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)., Diagnostics, 2019, 9 (3), pp. 73: 1-73: 14
dcterms.dateAccepted2019-07-03
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-01-22T00:32:41Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
gro.hasfulltextFull Text
gro.griffith.authorVallings, Rosamund


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