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dc.contributor.authorYada, Koichi
dc.contributor.authorRoberts, Llion Arwyn
dc.contributor.authorOginome, Natsumi
dc.contributor.authorSuzuki, Katsuhiko
dc.date.accessioned2020-01-22T22:42:34Z
dc.date.available2020-01-22T22:42:34Z
dc.date.issued2019
dc.identifier.issn2076-3921
dc.identifier.doi10.3390/antiox9010029
dc.identifier.urihttp://hdl.handle.net/10072/390759
dc.description.abstractThe purpose of this study was to investigate the effects of acacia polyphenol (AP) supplementation on exercise-induced oxidative stress in mouse liver and skeletal muscle. Plasma aspartate aminotransferase (AST), liver and skeletal muscle levels of thiobarbituric acid reactive substance (TBARS), and levels of skeletal muscle protein carbonyls increased immediately after exhaustive exercise. Exhaustive exercise also decreased liver glutathione (GSH). These results suggest that the exhaustive exercise used in this study induced tissue damage and oxidative stress. Contrary to our expectations, AP supplementation increased plasma AST and alanine aminotransferase activities, liver levels of TBARS, and protein carbonyls. Furthermore, AP supplementation decreased glutathione and glutathione peroxidase activity in the liver. On the other hand, AP supplementation decreased TBARS levels in skeletal muscle. These results suggest that oral high-dose AP administration decreased oxidative stress in skeletal muscle but induced oxidative stress in the liver and increased hepatotoxicity.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute
dc.publisher.placeSwitzerland
dc.relation.ispartofpagefrom29: 1
dc.relation.ispartofpageto29: 11
dc.relation.ispartofissue1
dc.relation.ispartofjournalAntioxidants
dc.relation.ispartofvolume9
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchcode3101
dc.subject.keywordsantioxidants
dc.subject.keywordsexhaustive exercise
dc.subject.keywordshepatotoxicity
dc.subject.keywordsoxidative stress
dc.subject.keywordspolyphenols
dc.titleEffect of Acacia Polyphenol Supplementation on Exercise-Induced Oxidative Stress in Mice Liver and Skeletal Muscle
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationYada, K; Roberts, LA; Oginome, N; Suzuki, K, Effect of Acacia Polyphenol Supplementation on Exercise-Induced Oxidative Stress in Mice Liver and Skeletal Muscle., Antioxidants, 2019, 9 (1), pp. 29: 1-29: 11
dcterms.dateAccepted2019-12-25
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-01-22T06:11:05Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2019 The Author(s). This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorRoberts, Llion A.


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