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dc.contributor.authorTomasetti, Marco
dc.contributor.authorGaetani, Simona
dc.contributor.authorMonaco, Federica
dc.contributor.authorNeuzil, Jiri
dc.contributor.authorSantarelli, Lory
dc.date.accessioned2020-01-22T22:46:57Z
dc.date.available2020-01-22T22:46:57Z
dc.date.issued2019
dc.identifier.issn2234-943X
dc.identifier.doi10.3389/fonc.2019.01293
dc.identifier.urihttp://hdl.handle.net/10072/390760
dc.description.abstractAsbestos exposure leads to epigenetic and epigenomic modifications that, in association with ROS-induced DNA damage, contribute to cancer onset. Few miRNAs epigenetically regulated in MM have been described in literature; miR-126, however, is one of them, and its expression is regulated by epigenetic mechanisms. Asbestos exposure induces early changes in the miRNAs, which are reversibly expressed as protective species, and their inability to reverse reflects the inability of the cells to restore the physiological miRNA levels despite the cessation of carcinogen exposure. Changes in miRNA expression, which results from genetic/epigenetic changes during tumor formation and evolution, can be detected in fluids and used as cancer biomarkers. This article has reviewed the epigenetic mechanisms involved in miRNA expression in MM, focusing on their role as biomarkers of early diagnosis and therapeutic effects.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherFrontiers Research Foundation
dc.publisher.placeSwitzerland
dc.relation.ispartofpagefrom1293: 1
dc.relation.ispartofpageto1293: 14
dc.relation.ispartofjournalFrontiers in Oncology
dc.relation.ispartofvolume9
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode1112
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsOncology
dc.subject.keywordsmalignant mesothelioma
dc.subject.keywordsepi-miRNAs
dc.titleEpigenetic Regulation of miRNA Expression in Malignant Mesothelioma: miRNAs as Biomarkers of Early Diagnosis and Therapy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationTomasetti, M; Gaetani, S; Monaco, F; Neuzil, J; Santarelli, L, Epigenetic Regulation of miRNA Expression in Malignant Mesothelioma: miRNAs as Biomarkers of Early Diagnosis and Therapy, Frontiers in Oncology, 2019, 9, pp. 1293: 1-1293: 14
dcterms.dateAccepted2019-11-07
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-01-22T06:15:16Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2019 Tomasetti, Gaetani, Monaco, Neuzil and Santarelli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
gro.hasfulltextFull Text
gro.griffith.authorNeuzil, Jiri


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