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dc.contributor.authorMcKeating, Daniel R
dc.contributor.authorFisher, Joshua J
dc.contributor.authorZhang, Ping
dc.contributor.authorBennett, William W
dc.contributor.authorPerkins, Anthony V
dc.date.accessioned2020-01-24T06:22:13Z
dc.date.available2020-01-24T06:22:13Z
dc.date.issued2020
dc.identifier.issn0946-672X
dc.identifier.doi10.1016/j.jtemb.2019.126419
dc.identifier.urihttp://hdl.handle.net/10072/390894
dc.description.abstractBackground: Trace elements are an essential requirement for human health and development and changes in trace element status have been associated with pregnancy complications such as gestational diabetes mellitus (GDM), pre-eclampsia (PE), fetal growth restriction (FGR), and preterm birth. Elemental metabolomics, which involves the simultaneous quantification and characterisation of multiple elements, could provide important insights into these gestational disorders. Methods: This study used an Agilent 7900 inductively coupled plasma mass spectrometer (ICP-MS) to simultaneously measure 68 elements, in 166 placental cord blood samples collected from women with various pregnancy complications (control, hypertensive, PE, GDM, FGR, pre-term, and post-term birth). Results: There were single element differences across gestational outcomes for elements Mg, P, Cr, Ni, Sr, Mo, I, Au, Pb, and U. Hypertensive and post-term pregnancies were significantly higher in Ni concentrations when compared to controls (control = 2.74 μg/L, hypertensive = 6.72 μg/L, post-term = 7.93 μg/L, p < 0.05), iodine concentration was significantly higher in post-term pregnancies (p < 0.05), and Pb concentrations were the lowest in pre-term pregnancies (pre-term = 2.79 μg/L, control = 4.68 μg/L, PE = 5.32 μg/L, GDM = 8.27 μg/L, p < 0.01). Further analysis was conducted using receiver operating characteristic (ROC) curves for differentiating pregnancy groups. The ratio of Sn/Pb showed the best diagnostic power in discriminating between control and pre-term birth with area under the curve (AUC) 0.86. When comparing control and post-term birth, Mg/Cr (AUC = 0.84), and Cr (AUC = 0.83) had the best diagnostic powers. In pre-term and post-term comparisons Ba was the best single element (81.5%), and P/Cu provided the best ratio (91.7%). Conclusions: This study has shown that analysis of multiple elements can enable differentiation between fetal cord blood samples from control, hypertensive, PE, GDM, FGR, pre and post-term pregnancies. This data highlights the power of elemental metabolomics and provides a basis for future gestational studies.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherElsevier
dc.relation.ispartofjournalJournal of Trace Elements in Medicine and Biology
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchcode0601
dc.subject.keywordsCord blood
dc.subject.keywordsElemental metabolomics
dc.subject.keywordsGestational disorders
dc.subject.keywordsPregnancy
dc.titleElemental metabolomics in human cord blood: Method validation and trace element quantification
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMcKeating, DR; Fisher, JJ; Zhang, P; Bennett, WW; Perkins, AV, Elemental metabolomics in human cord blood: Method validation and trace element quantification, Journal of Trace Elements in Medicine and Biology, 2019
dcterms.dateAccepted2019-10-18
dc.date.updated2020-01-24T06:16:25Z
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.hasfulltextNo Full Text
gro.griffith.authorBennett, Will W.
gro.griffith.authorMcKeating, Daniel R.
gro.griffith.authorFisher, Josh
gro.griffith.authorPerkins, Anthony V.
gro.griffith.authorZhang, Ping


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