Is total iron binding capacity (TIBC) calculation correct?
Author(s)
Rathnayake, Geetha
Badrick, Tony
Griffith University Author(s)
Year published
2019
Metadata
Show full item recordAbstract
As part of serum/plasma investigations to determine iron status, total iron binding capacity (TIBC) is an important calculation to determine percentage transferrin (TRF) saturation. TRF saturation may be the earliest indicator of iron overload and a low TRF saturation in the setting of an equivocal ferritin level is suggestive of iron deficiency. Serum/plasma TIBC (μmol/L) values could be either obtained from a calculation or measured by the amount of iron required to saturate the specimen. When TIBC is determined by calculation, the iron transport protein, TRF concentration (g/L), is multiplied by a conversion factor. ...
View more >As part of serum/plasma investigations to determine iron status, total iron binding capacity (TIBC) is an important calculation to determine percentage transferrin (TRF) saturation. TRF saturation may be the earliest indicator of iron overload and a low TRF saturation in the setting of an equivocal ferritin level is suggestive of iron deficiency. Serum/plasma TIBC (μmol/L) values could be either obtained from a calculation or measured by the amount of iron required to saturate the specimen. When TIBC is determined by calculation, the iron transport protein, TRF concentration (g/L), is multiplied by a conversion factor. Calculation has taken molecular mass and iron binding capacity of TRF into consideration to generate TIBC results in μmol/L.
View less >
View more >As part of serum/plasma investigations to determine iron status, total iron binding capacity (TIBC) is an important calculation to determine percentage transferrin (TRF) saturation. TRF saturation may be the earliest indicator of iron overload and a low TRF saturation in the setting of an equivocal ferritin level is suggestive of iron deficiency. Serum/plasma TIBC (μmol/L) values could be either obtained from a calculation or measured by the amount of iron required to saturate the specimen. When TIBC is determined by calculation, the iron transport protein, TRF concentration (g/L), is multiplied by a conversion factor. Calculation has taken molecular mass and iron binding capacity of TRF into consideration to generate TIBC results in μmol/L.
View less >
Journal Title
Pathology
Volume
51
Issue
4
Subject
Clinical sciences
Science & Technology
Life Sciences & Biomedicine
Pathology
SERUM TRANSFERRIN
SATURATION