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dc.contributor.authorFigueredo, CM
dc.contributor.authorLira-Junior, R
dc.contributor.authorLove, RM
dc.date.accessioned2020-01-30T03:18:46Z
dc.date.available2020-01-30T03:18:46Z
dc.date.issued2019
dc.identifier.issn1661-6596
dc.identifier.doi10.3390/ijms20163949
dc.identifier.urihttp://hdl.handle.net/10072/390975
dc.description.abstractPeriodontal disease is characterised by a dense inflammatory infiltrate in the connective tissue. When the resolution is not achieved, the activation of T and B cells is crucial in controlling chronic inflammation through constitutive cytokine secretion and modulation of osteoclastogenesis. The present narrative review aims to overview the recent findings of the importance of T and B cell subsets, as well as their cytokine expression, in the pathogenesis of the periodontal disease. T regulatory (Treg), CD8+ T, and tissue-resident γδ T cells are important to the maintenance of gingival homeostasis. In inflamed gingiva, however, the secretion of IL-17 and secreted osteoclastogenic factor of activated T cells (SOFAT) by activated T cells is crucial to induce osteoclastogenesis via RANKL activation. Moreover, the capacity of mucosal-associated invariant T cells (MAIT cells) to produce cytokines, such as IFN-γ, TNF-α, and IL-17, might indicate a critical role of such cells in the disease pathogenesis. Regarding B cells, low levels of memory B cells in clinically healthy periodontium seem to be important to avoid bone loss due to the subclinical inflammation that occurs. On the other hand, they can exacerbate alveolar bone loss in a receptor activator of nuclear factor kappa-B ligand (RANKL)-dependent manner and affect the severity of periodontitis. In conclusion, several new functions have been discovered and added to the complex knowledge about T and B cells, such as possible new functions for Tregs, the role of SOFAT, and MAIT cells, as well as B cells activating RANKL. The activation of distinct T and B cell subtypes is decisive in defining whether the inflammatory lesion will stabilise as chronic gingivitis or will progress to a tissue destructive periodontitis.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.publisher.placeSwitzerland
dc.relation.ispartofpagefrom3949:1
dc.relation.ispartofpageto3949:13
dc.relation.ispartofissue16
dc.relation.ispartofjournalInternational Journal of Molecular Sciences
dc.relation.ispartofvolume20
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchOther Chemical Sciences
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchOther Biological Sciences
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode0399
dc.subject.fieldofresearchcode0604
dc.subject.fieldofresearchcode0699
dc.subject.keywordsB cells
dc.subject.keywordsT cells
dc.subject.keywordscytokine
dc.subject.keywordslymphocyte
dc.subject.keywordsperiodontal disease
dc.titleT and B Cells in Periodontal Disease: New Functions in A Complex Scenario
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationFigueredo, CM; Lira-Junior, R; Love, RM, T and B Cells in Periodontal Disease: New Functions in A Complex Scenario., International Journal of Molecular Sciences, 2019, 20 (16), pp. 3949:1-3949:13
dcterms.dateAccepted2019-08-13
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-01-30T03:16:24Z
dc.description.versionPublished
gro.rights.copyright© The Author(s). 2019. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorda Silva Figueredo, Carlos Marcelo
gro.griffith.authorLove, Robert M.


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