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  • The Dosage of the Derivative of Clostridium Ghonii (DCG) Spores Dictates Whether an IFN/IL-9 or a Strong IFN Response Is Elicited in TC-1 Tumour Bearing Mice

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    Author(s)
    Ni, Guoying
    Wang, Yong
    Good, David
    Yuan, Jianwei
    Pan, Xuan
    Wei, Jou
    Liu, Xiaosong
    Wei, Ming Q
    Griffith University Author(s)
    Good, David A.
    Wei, Ming Q.
    Ni, Guoying
    Year published
    2019
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    Abstract
    Background. Anaerobic Clostridial spores (CG) cause significant oncolysis in hypoxic tumour microenvironment and result in tumour regression in both animal models and clinical trials. The immune mediated response plays a critical role in the antitumour effect by the anaerobic spore treatment. Method. Human papillomavirus 16 E6/E7 transformed TC-1 tumour bearing mice were intravenously administered with low (1 × 108 CFU/kg) or high dosage (3 × 108 CFU/kg) of Derivative Clostridial spore (DCG). Results. Intravenous administration of the derivative of Clostridial ghonii (DCG) spores leads to both tumour and systemic inflammatory ...
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    Background. Anaerobic Clostridial spores (CG) cause significant oncolysis in hypoxic tumour microenvironment and result in tumour regression in both animal models and clinical trials. The immune mediated response plays a critical role in the antitumour effect by the anaerobic spore treatment. Method. Human papillomavirus 16 E6/E7 transformed TC-1 tumour bearing mice were intravenously administered with low (1 × 108 CFU/kg) or high dosage (3 × 108 CFU/kg) of Derivative Clostridial spore (DCG). Results. Intravenous administration of the derivative of Clostridial ghonii (DCG) spores leads to both tumour and systemic inflammatory responses characterized by increased IFNγ/IL-9 secreting T cells in the spleen and the tumour. Low numbers of antigen specific T cells (<20/106 spleen cells) in the spleen of the tumour bearing mice are also detected after intravenous DCG delivery. Interestingly, our results showed that a mixed IL-9/IFNγ secreting T cell response was induced when the tumour bearing mice received a low dose of DCG spore (1 × 108 CFU/kg), while a strong IFNγ response was elicited with a high dosage of DCG spore (3 × 108 CFU/kg). Conclusion. The dosage of DCG spore will determine the types of the DCG induced immune responses.
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    Journal Title
    BioMed Research International
    Volume
    2019
    DOI
    https://doi.org/10.1155/2019/1395138
    Copyright Statement
    © 2019 Guoying Ni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Biological sciences
    Science & Technology
    Life Sciences & Biomedicine
    Biotechnology & Applied Microbiology
    Medicine, Research & Experimental
    Research & Experimental Medicine
    Publication URI
    http://hdl.handle.net/10072/390979
    Collection
    • Journal articles

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