dc.contributor.author | Naruse, H | |
dc.contributor.author | Ishii, J | |
dc.contributor.author | Takahashi, H | |
dc.contributor.author | Kitagawa, F | |
dc.contributor.author | Nishimura, H | |
dc.contributor.author | Kawai, H | |
dc.contributor.author | Muramatsu, T | |
dc.contributor.author | Harada, M | |
dc.contributor.author | Yamada, A | |
dc.contributor.author | Motoyama, S | |
dc.contributor.author | Matsui, S | |
dc.contributor.author | Hayashi, M | |
dc.contributor.author | Sarai, M | |
dc.contributor.author | Watanabe, E | |
dc.contributor.author | Izawa, H | |
dc.contributor.author | Ozaki, Y | |
dc.date.accessioned | 2020-02-04T00:37:44Z | |
dc.date.available | 2020-02-04T00:37:44Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1364-8535 | |
dc.identifier.doi | 10.1186/s13054-018-2120-z | |
dc.identifier.uri | http://hdl.handle.net/10072/391086 | |
dc.description.abstract | Background: The early prediction of acute kidney injury (AKI) can facilitate timely intervention and prevent complications. We aimed to understand the predictive value of urinary liver-type fatty-acid binding protein (L-FABP) levels on admission to medical (non-surgical) cardiac intensive care units (CICUs) for AKI, both independently and in combination with serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. Methods: We prospectively investigated the predictive value of L-FABP and NT-proBNP for AKI in a large, heterogeneous cohort of patients treated in medical CICUs. Baseline urinary L-FABP and serum NT-proBNP were measured on admission. AKI was diagnosed according to the Kidney Disease: Improving Global Outcomes criteria. We studied 1273 patients (mean age, 68years), among whom 46% had acute coronary syndromes, 38% had acute decompensated heart failure, 5% had arrhythmia, 3% had pulmonary hypertension, 2% had acute aortic syndrome, 2% had infective endocarditis, and 1% had Takotsubo cardiomyopathy. Results: Urinary L-FABP levels correlated with serum NT-proBNP levels (r=0.17, p<0.0001). AKI occurred in 224 patients (17.6%), including 48 patients with stage 2 or 3 disease. Patients who developed AKI had higher one-week and 6-month mortality than those who did not develop AKI (p=0.0002 and p=0.003, respectively). In the multivariate logistic analysis, both L-FABP (p<0.0001) and NT-proBNP (p=0.006) were independently associated with the development of AKI. Adding L-FABP and NT-proBNP to a baseline model that included established risk factors further improved reclassification (p<0.001) and discrimination (p<0.01) beyond that of the baseline model or any single biomarker individually. Conclusions: Urinary L-FABP and serum NT-proBNP levels on admission are independent predictors of AKI, and when used in combination, improve early prediction of AKI in patients hospitalized at medical CICUs. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | BioMed Central | |
dc.publisher.place | United Kingdom | |
dc.relation.ispartofpagefrom | 197:1 | |
dc.relation.ispartofpageto | 197:10 | |
dc.relation.ispartofissue | 1 | |
dc.relation.ispartofjournal | Critical Care | |
dc.relation.ispartofvolume | 22 | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearchcode | 32 | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.keywords | Acute kidney injury | |
dc.subject.keywords | Liver-type fatty-acid binding protein | |
dc.subject.keywords | Medical cardiac intensive care units | |
dc.subject.keywords | N-terminal pro-B-type natriuretic peptide | |
dc.title | Predicting acute kidney injury using urinary liver-type fatty-acid binding protein and serum N-terminal pro-B-type natriuretic peptide levels in patients treated at medical cardiac intensive care units | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Naruse, H; Ishii, J; Takahashi, H; Kitagawa, F; Nishimura, H; Kawai, H; Muramatsu, T; Harada, M; Yamada, A; Motoyama, S; Matsui, S; Hayashi, M; Sarai, M; Watanabe, E; Izawa, H; Ozaki, Y, Predicting acute kidney injury using urinary liver-type fatty-acid binding protein and serum N-terminal pro-B-type natriuretic peptide levels in patients treated at medical cardiac intensive care units, Critical Care, 2018, 22 (1), pp. 197:1-197:10 | |
dcterms.dateAccepted | 2018-07-03 | |
dcterms.license | http://creativecommons.org/licenses/by/4.0/ | |
dc.date.updated | 2020-02-04T00:07:39Z | |
dc.description.version | Version of Record (VoR) | |
gro.rights.copyright | © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Yamada, Akira | |