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dc.contributor.authorLan, Qin
dc.contributor.authorWu, Hong
dc.contributor.authorZhou, Xiaohui
dc.contributor.authorZheng, Liang
dc.contributor.authorLin, Fang
dc.contributor.authorMeng, Qingshu
dc.contributor.authorXi, Xiaoling
dc.contributor.authorYue, Aixue
dc.contributor.authorBuys, Nicholas
dc.contributor.authorSun, Jing
dc.contributor.authorLiu, Zhongmin
dc.contributor.authorLi, Jue
dc.contributor.authorFan, Huimin
dc.date.accessioned2020-02-06T01:12:35Z
dc.date.available2020-02-06T01:12:35Z
dc.date.issued2020
dc.identifier.issn2296-858X
dc.identifier.doi10.3389/fmed.2020.00024
dc.identifier.urihttp://hdl.handle.net/10072/391127
dc.description.abstractAim: This study aimed to test the predictive power of serum uric acid (UA) levels on new-onset cardiometabolic risk in the Chinese population. Methods: Older people who visited a community health center for a yearly health check (N = 5,000; men: 47%, women: 53%) were enrolled. Participants were followed for 4 years from baseline (median: 48 months), with the endpoints being development of heart failure, atrial fibrillation, diabetes, hypertension, metabolic syndrome, or kidney disease. Results: During follow-up, 342 men (7.4%) and 360 women (8.6%) developed hypertension; 98 men (2.48%) and 135 women (3.06%) developed diabetes; and 175 men (5.04%) and 214 women (4.51%) developed metabolic syndrome. Incident diabetes, hypertension, and metabolic syndrome increased with increased UA levels at baseline (P < 0.001). A multivariate Cox proportional hazards analysis revealed a significant, independent association between the baseline UA level and the onset and future hypertension and/or diabetes in both men and women. However, UA is associated with the development of metabolic syndrome in men, but not in women. Conclusion: UA is an independent predictor of new-onset diabetes and hypertension in both women and men and a predictor of new-onset metabolic syndrome only in men.
dc.description.peerreviewedYes
dc.description.sponsorshipGriffith University
dc.description.sponsorshipGriffith University
dc.languageEnglish
dc.language.isoeng
dc.publisherFrontiers Media SA
dc.relation.ispartofjournalFrontiers in Medicine
dc.relation.ispartofvolume7
dc.subject.fieldofresearchCardiology (incl. Cardiovascular Diseases)
dc.subject.fieldofresearchEpidemiology
dc.subject.fieldofresearchcode110201
dc.subject.fieldofresearchcode111706
dc.titlePredictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationLan, Q; Wu, H; Zhou, X; Zheng, L; Lin, F; Meng, Q; Xi, X; Yue, A; Buys, N; Sun, J; Liu, Z; Li, J; Fan, H, Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study, Frontiers in Medicine, 7
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-02-05T23:12:42Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020 Lan, Wu, Zhou, Zheng, Lin, Meng, Xi, Yue, Buys, Sun, Liu, Li and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
gro.hasfulltextFull Text
gro.griffith.authorSun, Jing
gro.griffith.authorBuys, Nicholas J.


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