dc.contributor.author | Donato, Peter | |
dc.contributor.author | Morton, Andrew | |
dc.contributor.author | Yaxley, John | |
dc.contributor.author | Ranasinghe, Sachinka | |
dc.contributor.author | Teloken, Patrick E | |
dc.contributor.author | Kyle, Samuel | |
dc.contributor.author | Coughlin, Geoff | |
dc.contributor.author | Esler, Rachel | |
dc.contributor.author | Dunglison, Nigel | |
dc.contributor.author | Gardiner, Robert A | |
dc.contributor.author | Roberts, Matthew J | |
dc.date.accessioned | 2020-02-07T05:13:11Z | |
dc.date.available | 2020-02-07T05:13:11Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1619-7070 | |
dc.identifier.doi | 10.1007/s00259-019-04620-0 | |
dc.identifier.uri | http://hdl.handle.net/10072/391225 | |
dc.description.abstract | BACKGROUND: 68Ga prostate specific membrane antigen PET/CT (68Ga-PSMA PET/CT) may be superior to multiparametric MRI (mpMRI) for localisation of prostate cancer tumour foci, however the concordance and differences between 68Ga-PSMA PET/CT and mpMRI when applied to all biopsied patients and potential benefit in patients with negative mpMRI is unclear. METHODS: Retrospective analysis of patients undergoing mpMRI, prostate biopsy and 68Ga-PSMA PET/CT over a 3-year period. Diagnostic performance of 68Ga-PSMA PET/CT and mpMRI were assessed using biopsy histopathology for the entire cohort and radical prostatectomy specimen in a subset of patients. Lesion concordance and additional detection of each modality were determined, including in a dedicated cohort of patients with mpMRI PIRADS 2 scans. RESULTS: A total of 144 patients were included in the study. Index lesion/foci detection was similar between 68Ga-PSMA PET/CT and mpMRI (sensitivity 83.1% vs 90.1%; p = 0.267), however lesions missed by mpMRI were larger (1.66 cm3 vs 0.72 cm3; p = 0.034). Lesion detection rates were similar across the biopsy histopathology and radical prostatectomy specimen subset, with a high concordance for index (80.1%) and a moderate concordance for total (67%) lesions between the 2 imaging modalities. The additional detection yield favoured 68Ga-PSMA PET/CT over mpMRI for index (13.5% vs 4.3%) and total (18.2% vs 5.4%) lesions; both modalities missed 2.1% and 12.3% of index and total lesions, respectively. 68Ga-PSMA PET/CT identified 9 of 11 patients with PIRADS 2 mpMRI but subsequently diagnosed with Gleason ≥ 3 + 4 disease. CONCLUSIONS: Despite high concordance rates, 68Ga-PSMA PET/CT incrementally improved tumour localisation compared with mpMRI. These results suggest that 68Ga-PSMA PET/CT may have an incremental value to that of mpMRI in the diagnostic process for prostate. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Springer | |
dc.publisher.place | Germany | |
dc.relation.ispartofjournal | European Journal of Nuclear Medicine and Molecular Imaging | |
dc.subject.fieldofresearch | Other physical sciences | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearchcode | 5199 | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.keywords | Glutamate carboxypeptidase II | |
dc.subject.keywords | Human | |
dc.subject.keywords | Magnetic resonance imaging | |
dc.subject.keywords | Positron-emission tomography | |
dc.subject.keywords | Prostate specific membrane antigen | |
dc.title | 68Ga-PSMA PET/CT better characterises localised prostate cancer after MRI and transperineal prostate biopsy: Is 68Ga-PSMA PET/CT guided biopsy the future? | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Donato, P; Morton, A; Yaxley, J; Ranasinghe, S; Teloken, PE; Kyle, S; Coughlin, G; Esler, R; Dunglison, N; Gardiner, RA; Roberts, MJ, 68Ga-PSMA PET/CT better characterises localised prostate cancer after MRI and transperineal prostate biopsy: Is 68Ga-PSMA PET/CT guided biopsy the future?, European Journal of Nuclear Medicine and Molecular Imaging, 2020 | |
dcterms.dateAccepted | 2019-11-12 | |
dc.date.updated | 2020-02-07T01:52:53Z | |
gro.description.notepublic | This publication has been entered into Griffith Research Online as an Advanced Online Version | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Gardiner, Robert A. | |