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dc.contributor.authorDonato, Peter
dc.contributor.authorMorton, Andrew
dc.contributor.authorYaxley, John
dc.contributor.authorRanasinghe, Sachinka
dc.contributor.authorTeloken, Patrick E
dc.contributor.authorKyle, Samuel
dc.contributor.authorCoughlin, Geoff
dc.contributor.authorEsler, Rachel
dc.contributor.authorDunglison, Nigel
dc.contributor.authorGardiner, Robert A
dc.contributor.authorRoberts, Matthew J
dc.date.accessioned2020-02-07T05:13:11Z
dc.date.available2020-02-07T05:13:11Z
dc.date.issued2020
dc.identifier.issn1619-7070
dc.identifier.doi10.1007/s00259-019-04620-0
dc.identifier.urihttp://hdl.handle.net/10072/391225
dc.description.abstractBACKGROUND: 68Ga prostate specific membrane antigen PET/CT (68Ga-PSMA PET/CT) may be superior to multiparametric MRI (mpMRI) for localisation of prostate cancer tumour foci, however the concordance and differences between 68Ga-PSMA PET/CT and mpMRI when applied to all biopsied patients and potential benefit in patients with negative mpMRI is unclear. METHODS: Retrospective analysis of patients undergoing mpMRI, prostate biopsy and 68Ga-PSMA PET/CT over a 3-year period. Diagnostic performance of 68Ga-PSMA PET/CT and mpMRI were assessed using biopsy histopathology for the entire cohort and radical prostatectomy specimen in a subset of patients. Lesion concordance and additional detection of each modality were determined, including in a dedicated cohort of patients with mpMRI PIRADS 2 scans. RESULTS: A total of 144 patients were included in the study. Index lesion/foci detection was similar between 68Ga-PSMA PET/CT and mpMRI (sensitivity 83.1% vs 90.1%; p = 0.267), however lesions missed by mpMRI were larger (1.66 cm3 vs 0.72 cm3; p = 0.034). Lesion detection rates were similar across the biopsy histopathology and radical prostatectomy specimen subset, with a high concordance for index (80.1%) and a moderate concordance for total (67%) lesions between the 2 imaging modalities. The additional detection yield favoured 68Ga-PSMA PET/CT over mpMRI for index (13.5% vs 4.3%) and total (18.2% vs 5.4%) lesions; both modalities missed 2.1% and 12.3% of index and total lesions, respectively. 68Ga-PSMA PET/CT identified 9 of 11 patients with PIRADS 2 mpMRI but subsequently diagnosed with Gleason ≥ 3 + 4 disease. CONCLUSIONS: Despite high concordance rates, 68Ga-PSMA PET/CT incrementally improved tumour localisation compared with mpMRI. These results suggest that 68Ga-PSMA PET/CT may have an incremental value to that of mpMRI in the diagnostic process for prostate.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeGermany
dc.relation.ispartofjournalEuropean Journal of Nuclear Medicine and Molecular Imaging
dc.subject.fieldofresearchOther physical sciences
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode5199
dc.subject.fieldofresearchcode3202
dc.subject.keywordsGlutamate carboxypeptidase II
dc.subject.keywordsHuman
dc.subject.keywordsMagnetic resonance imaging
dc.subject.keywordsPositron-emission tomography
dc.subject.keywordsProstate specific membrane antigen
dc.title68Ga-PSMA PET/CT better characterises localised prostate cancer after MRI and transperineal prostate biopsy: Is 68Ga-PSMA PET/CT guided biopsy the future?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationDonato, P; Morton, A; Yaxley, J; Ranasinghe, S; Teloken, PE; Kyle, S; Coughlin, G; Esler, R; Dunglison, N; Gardiner, RA; Roberts, MJ, 68Ga-PSMA PET/CT better characterises localised prostate cancer after MRI and transperineal prostate biopsy: Is 68Ga-PSMA PET/CT guided biopsy the future?, European Journal of Nuclear Medicine and Molecular Imaging, 2020
dcterms.dateAccepted2019-11-12
dc.date.updated2020-02-07T01:52:53Z
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version
gro.hasfulltextNo Full Text
gro.griffith.authorGardiner, Robert A.


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