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dc.contributor.authorPingel, Jessica
dc.contributor.authorBarber, Lee
dc.contributor.authorAndersen, Ida Torp
dc.contributor.authorVon Walden, Ferdinand
dc.contributor.authorWong, Christian
dc.contributor.authorDossing, Simon
dc.contributor.authorNielsen, Jens Bo
dc.date.accessioned2020-02-10T04:30:47Z
dc.date.available2020-02-10T04:30:47Z
dc.date.issued2019
dc.identifier.issn2058-7392en_US
dc.identifier.doi10.1177/2058739218823474en_US
dc.identifier.urihttp://hdl.handle.net/10072/391279
dc.description.abstractIndividuals with cerebral palsy (CP) develop skeletal muscle contractures that impair muscle function. In turn, contractures affect the ability to ambulate and often promote a sedentary lifestyle. The aim of the present study was to investigate the systemic inflammatory markers transforming growth factor beta-1 (TGFβ1), C-reactive protein (CRP), and interleukin-6 (IL-6) in children and adults with CP. Blood samples of n = 34 participants (24 individuals with CP (n = 14 children with CP age 10.36 ± 1.1 and n = 10 adults with CP age 38.80 ± 3.6) and 10 healthy adults age 36.63 ± 3.8) were analyzed for circulating levels of TGFβ1, CRP, and IL-6 using Sandwich Enzyme linked immunosorbent assay (ELISA) analyses (R&D systems). TGFβ1 and CRP levels were significantly higher in children with CP compared to both adults with CP (TGFβ1: P < 0.0005 and P < 0.0002, respectively) and healthy adults (CRP: P < 0.0001 and P < 0.0001, respectively), while no differences were observed between the adults with CP and healthy adults in TGFβ1 (P = 0.29) and CRP (P = 0.59), respectively. Furthermore, IL-6 levels showed no significant differences between the groups. The present findings indicate that the level of systemic inflammation is increased in children with CP. We speculate that persisting inflammation in children with CP might influence the development of muscle contractures, resulting in reduced muscle mass and marked muscle weakness in adults with CP.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.language.isoeng
dc.publisherSageen_US
dc.relation.ispartofjournalEuropean Journal of Inflammationen_US
dc.relation.ispartofvolume17en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsImmunologyen_US
dc.subject.keywordscerebral palsyen_US
dc.subject.keywordsC-reactive proteinen_US
dc.titleSystemic inflammatory markers in individuals with cerebral palsyen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationPingel, J; Barber, L; Andersen, IT; Von Walden, F; Wong, C; Dossing, S; Nielsen, JB, Systemic inflammatory markers in individuals with cerebral palsy, European Journal of Inflammation, 2019, 17en_US
dcterms.licensehttp://www.creativecommons.org/licenses/by-nc/4.0/en_US
dc.date.updated2020-02-10T04:27:01Z
dc.description.versionVersion of Record (VoR)en_US
gro.rights.copyright© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License, which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).en_US
gro.hasfulltextFull Text
gro.griffith.authorBarber, Lee A.


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