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  • Convergence of Scaffold-Guided Bone Reconstruction and Surgical Vascularization Strategies-A Quest for Regenerative Matching Axial Vascularization

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    Author(s)
    Sparks, David S
    Savi, Flavia Medeiros
    Saifzadeh, Siamak
    Schuetz, Michael A
    Wagels, Michael
    Hutmacher, Dietmar W
    Griffith University Author(s)
    Hutmacher, Dietmar W.
    Year published
    2020
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    Abstract
    The prevalent challenge facing tissue engineering today is the lack of adequate vascularization to support the growth, function, and viability of tissue engineered constructs (TECs) that require blood vessel supply. The research and clinical community rely on the increasing knowledge of angiogenic and vasculogenic processes to stimulate a clinically-relevant vascular network formation within TECs. The regenerative matching axial vascularization approach presented in this manuscript incorporates the advantages of flap-based techniques for neo-vascularization yet also harnesses the in vivo bioreactor principle in a more directed ...
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    The prevalent challenge facing tissue engineering today is the lack of adequate vascularization to support the growth, function, and viability of tissue engineered constructs (TECs) that require blood vessel supply. The research and clinical community rely on the increasing knowledge of angiogenic and vasculogenic processes to stimulate a clinically-relevant vascular network formation within TECs. The regenerative matching axial vascularization approach presented in this manuscript incorporates the advantages of flap-based techniques for neo-vascularization yet also harnesses the in vivo bioreactor principle in a more directed “like for like” approach to further assist regeneration of the specific tissue type that is lost, such as a corticoperiosteal flap in critical sized bone defect reconstruction.
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    Journal Title
    Frontiers in Bioengineering and Biotechnology
    Volume
    7
    DOI
    https://doi.org/10.3389/fbioe.2019.00448
    Copyright Statement
    © 2020 Sparks, Savi, Saifzadeh, Schuetz, Wagels and Hutmacher. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
    Subject
    Other biological sciences
    Biomedical engineering
    Medical biotechnology
    Clinical sciences
    ARTERIOVENOUS SHUNT LOOP
    TISSUE-ENGINEERED BONE
    DE-NOVO GENERATION
    IN-VIVO BIOREACTOR
    MANDIBULAR RECONSTRUCTION
    Publication URI
    http://hdl.handle.net/10072/391347
    Collection
    • Journal articles

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