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  • Microparticles for Sustained Growth Factor Delivery in the Regeneration of Critically-Sized Segmental Tibial Bone Defects

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    Author(s)
    Kirby, Giles TS
    White, Lisa J
    Steck, Roland
    Berner, Arne
    Bogoevski, Kristofor
    Qutachi, Omar
    Jones, Brendan
    Saifzadeh, Siamak
    Hutmacher, DietmarW
    Shakesheff, Kevin M
    Woodruff, Maria A
    Griffith University Author(s)
    Hutmacher, Dietmar W.
    Year published
    2016
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    Abstract
    This study trialled the controlled delivery of growth factors within a biodegradable scaffold in a large segmental bone defect model. We hypothesised that co-delivery of vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) followed by bone morphogenetic protein-2 (BMP-2) could be more effective in stimulating bone repair than the delivery of BMP-2 alone. Poly(lactic-co-glycolic acid) (PLGA ) based microparticles were used as a delivery system to achieve a controlled release of growth factors within a medical-grade Polycaprolactone (PCL) scaffold. The scaffolds were assessed in a well-established ...
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    This study trialled the controlled delivery of growth factors within a biodegradable scaffold in a large segmental bone defect model. We hypothesised that co-delivery of vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) followed by bone morphogenetic protein-2 (BMP-2) could be more effective in stimulating bone repair than the delivery of BMP-2 alone. Poly(lactic-co-glycolic acid) (PLGA ) based microparticles were used as a delivery system to achieve a controlled release of growth factors within a medical-grade Polycaprolactone (PCL) scaffold. The scaffolds were assessed in a well-established preclinical ovine tibial segmental defect measuring 3 cm. After six months, mechanical properties and bone tissue regeneration were assessed. Mineralised bone bridging of the defect was enhanced in growth factor treated groups. The inclusion of VEGF and PDGF (with BMP-2) had no significant effect on the amount of bone regeneration at the six-month time point in comparison to BMP-2 alone. However, regions treated with VEGF and PDGF showed increased vascularity. This study demonstrates an effective method for the controlled delivery of therapeutic growth factors in vivo, using microparticles.
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    Journal Title
    Materials
    Volume
    9
    Issue
    4
    DOI
    https://doi.org/10.3390/ma9040259
    Copyright Statement
    © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Biomedical engineering
    Clinical sciences
    Medical physiology
    Science & Technology
    Technology
    Materials Science, Multidisciplinary
    Materials Science
    growth factor
    Publication URI
    http://hdl.handle.net/10072/391470
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    • Journal articles

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