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dc.contributor.authorKirby, Giles TS
dc.contributor.authorWhite, Lisa J
dc.contributor.authorSteck, Roland
dc.contributor.authorBerner, Arne
dc.contributor.authorBogoevski, Kristofor
dc.contributor.authorQutachi, Omar
dc.contributor.authorJones, Brendan
dc.contributor.authorSaifzadeh, Siamak
dc.contributor.authorHutmacher, DietmarW
dc.contributor.authorShakesheff, Kevin M
dc.contributor.authorWoodruff, Maria A
dc.date.accessioned2020-02-14T03:00:01Z
dc.date.available2020-02-14T03:00:01Z
dc.date.issued2016
dc.identifier.issn1932-6254
dc.identifier.doi10.3390/ma9040259
dc.identifier.urihttp://hdl.handle.net/10072/391470
dc.description.abstractThis study trialled the controlled delivery of growth factors within a biodegradable scaffold in a large segmental bone defect model. We hypothesised that co-delivery of vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) followed by bone morphogenetic protein-2 (BMP-2) could be more effective in stimulating bone repair than the delivery of BMP-2 alone. Poly(lactic-co-glycolic acid) (PLGA ) based microparticles were used as a delivery system to achieve a controlled release of growth factors within a medical-grade Polycaprolactone (PCL) scaffold. The scaffolds were assessed in a well-established preclinical ovine tibial segmental defect measuring 3 cm. After six months, mechanical properties and bone tissue regeneration were assessed. Mineralised bone bridging of the defect was enhanced in growth factor treated groups. The inclusion of VEGF and PDGF (with BMP-2) had no significant effect on the amount of bone regeneration at the six-month time point in comparison to BMP-2 alone. However, regions treated with VEGF and PDGF showed increased vascularity. This study demonstrates an effective method for the controlled delivery of therapeutic growth factors in vivo, using microparticles.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofissue4
dc.relation.ispartofjournalMaterials
dc.relation.ispartofvolume9
dc.subject.fieldofresearchBiomedical Engineering
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchMedical Physiology
dc.subject.fieldofresearchcode0903
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1116
dc.subject.keywordsScience & Technology
dc.subject.keywordsTechnology
dc.subject.keywordsMaterials Science, Multidisciplinary
dc.subject.keywordsMaterials Science
dc.subject.keywordsgrowth factor
dc.titleMicroparticles for Sustained Growth Factor Delivery in the Regeneration of Critically-Sized Segmental Tibial Bone Defects
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationKirby, GTS; White, LJ; Steck, R; Berner, A; Bogoevski, K; Qutachi, O; Jones, B; Saifzadeh, S; Hutmacher, D; Shakesheff, KM; Woodruff, MA, Microparticles for Sustained Growth Factor Delivery in the Regeneration of Critically-Sized Segmental Tibial Bone Defects, Materials, 2016, 9 (4)
dcterms.dateAccepted2016-03-18
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-02-14T02:57:25Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2016 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorHutmacher, Dietmar W.


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