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dc.contributor.authorTang, Kai-Dun
dc.contributor.authorHolzapfel, Boris M
dc.contributor.authorLiu, Ji
dc.contributor.authorLee, Terence Kin-Wah
dc.contributor.authorMa, Stephanie
dc.contributor.authorJovanovic, Lidija
dc.contributor.authorAn, Jiyuan
dc.contributor.authorRussell, Pamela J
dc.contributor.authorClements, Judith A
dc.contributor.authorHutmacher, Dietmar W
dc.contributor.authorLing, Ming-Tat
dc.date.accessioned2020-02-17T02:42:15Z
dc.date.available2020-02-17T02:42:15Z
dc.date.issued2016
dc.identifier.issn1949-2553
dc.identifier.doi10.18632/oncotarget.3950
dc.identifier.urihttp://hdl.handle.net/10072/391562
dc.description.abstractAmple evidence supports that prostate tumor metastasis originates from a rare population of cancer cells, known as cancer stem cells (CSCs). Unfortunately, little is known about the identity of these cells, making it difficult to target the metastatic prostate tumor. Here, for the first time, we report the identification of a rare population of prostate cancer cells that express the Tie-2 protein. We found that this Tie-2High population exists mainly in prostate cancer cell lines that are capable of metastasizing to the bone. These cells not only express a higher level of CSC markers but also demonstrate enhanced resistance to the chemotherapeutic drug Cabazitaxel. In addition, knockdown of the expression of the Tie-2 ligand angiopoietin (Ang-1) led to suppression of CSC markers, suggesting that the Ang-1/Tie-2 signaling pathway functions as an autocrine loop for the maintenance of prostate CSCs. More importantly, we found that Tie-2High prostate cancer cells are more adhesive than the Tie-2Low population to both osteoblasts and endothelial cells. Moreover, only the Tie-2High, but not the Tie-2Low cells developed tumor metastasis in vivo when injected at a low number. Taken together, our data suggest that Tie-2 may play an important role during the development of prostate tumor metastasis.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherImpact Journals, LLC
dc.relation.ispartofpagefrom2572
dc.relation.ispartofpageto2584
dc.relation.ispartofissue3
dc.relation.ispartofjournalOncotarget
dc.relation.ispartofvolume7
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode1112
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsOncology
dc.subject.keywordsCell Biology
dc.subject.keywordsTie-2
dc.titleTie-2 regulates the stemness and metastatic properties of prostate cancer cells
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationTang, K-D; Holzapfel, BM; Liu, J; Lee, TK-W; Ma, S; Jovanovic, L; An, J; Russell, PJ; Clements, JA; Hutmacher, DW; Ling, M-T, Tie-2 regulates the stemness and metastatic properties of prostate cancer cells, Oncotarget, 2016, 7 (3), pp. 2572-2584
dcterms.dateAccepted2015-04-08
dcterms.licensehttp://creativecommons.org/licenses/by/3.0/
dc.date.updated2020-02-17T02:40:21Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2015 Tang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
gro.hasfulltextFull Text
gro.griffith.authorHutmacher, Dietmar W.
gro.griffith.authorAn, Jay


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