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dc.contributor.authorHoetker, David
dc.contributor.authorChung, Weiliang
dc.contributor.authorZhang, Deqing
dc.contributor.authorZhao, Jingjing
dc.contributor.authorSchmidtke, Virginia K
dc.contributor.authorRiggs, Daniel W
dc.contributor.authorDerave, Wim
dc.contributor.authorBhatnagar, Aruni
dc.contributor.authorBishop, David
dc.contributor.authorBaba, Shahid P
dc.description.abstractCarnosine and anserine are dipeptides synthesized from histidine and β-alanine by carnosine synthase (ATPGD1). These dipeptides, present in high concentration in the skeletal muscle, form conjugates with lipid peroxidation products such as 4-hydroxy trans-2-nonenal (HNE). Although skeletal muscle levels of these dipeptides could be elevated by feeding β-alanine, it is unclear how these dipeptides and their conjugates are affected by exercise training with or without β-alanine supplementation. We recruited twenty physically active men, who were allocated to either β-alanine or placebo-feeding group matched for VO2 peak, lactate threshold, and maximal power (Wmax). Participants completed 2 weeks of conditioning phase followed by 1 week of exercise testing (CPET) and a single session followed by 6 weeks of high intensity interval training (HIIT). Analysis of muscle biopsies showed that the levels of carnosine and ATPGD1 expression were increased after CPET and decreased following a single session and 6 weeks of HIIT. Expression of ATPGD1 and levels of carnosine were increased upon β-alanine-feeding after CPET, while ATPGD1 expression decreased following a single session of HIIT. The expression of fiber type markers myosin heavy chain (MHC) I and IIa remained unchanged after CPET. Levels of carnosine, anserine, carnosine-HNE, carnosine-propanal and carnosine-propanol were further increased after 9 weeks of β-alanine supplementation and exercise training, but remained unchanged in the placebo-fed group. These results suggest that carnosine levels and ATPGD1 expression fluctuates with different phases of training. Enhancing carnosine levels by β-alanine feeding could facilitate the detoxification of lipid peroxidation products in the human skeletal muscle.
dc.publisherAmerican Physical Society
dc.relation.ispartofjournalJournal of Applied Physiology
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsSport Sciences
dc.titleExercise alters and beta-alanine combined with exercise augments histidyl dipeptide levels and scavenges lipid peroxidation products in human skeletal muscle
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationHoetker, D; Chung, W; Zhang, D; Zhao, J; Schmidtke, VK; Riggs, DW; Derave, W; Bhatnagar, A; Bishop, D; Baba, SP, Exercise alters and beta-alanine combined with exercise augments histidyl dipeptide levels and scavenges lipid peroxidation products in human skeletal muscle, Journal of Applied Physiology, 2018, 125 (6), pp. 1767-1778
gro.hasfulltextNo Full Text
gro.griffith.authorDerave, Wim

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