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dc.contributor.authorAlizad, Vida
dc.contributor.authorMeinzer, Marcus
dc.contributor.authorFrossard, Laurent
dc.contributor.authorPolman, Remco
dc.contributor.authorSmith, Simon
dc.contributor.authorKerr, Graham
dc.date.accessioned2020-02-18T05:36:45Z
dc.date.available2020-02-18T05:36:45Z
dc.date.issued2018
dc.identifier.issn1745-6215
dc.identifier.doi10.1186/s13063-018-2982-z
dc.identifier.urihttp://hdl.handle.net/10072/391666
dc.description.abstractBackground: Gait difficulties are common and frequently devastating to people with Parkinson's disease (PD). These difficulties are often followed by an increased risk of falls, leading to injury, hospitalization and mortality. The dysfunction in the basal ganglia-thalamocortical motor circuits and reduced activity in the premotor and primary motor cortices has raised interest in transcranial direct current stimulation (tDCS) as an adjunct intervention in PD. tDCS might provide a potentially safe and non-invasive treatment by modulating cortical excitability and behavioural outcomes. The aim of this study is to compare the effects of different monopolar and bipolar montages of tDCS administered to the motor cortex and cerebellum on gait speed in PD. Methods: This study will be conducted in a randomized, double-blind cross-over design. Eighteen participants diagnosed with Parkinson's disease will receive anodal and sham tDCS (1 mA, 20 min, 10 × 4 cm 2 ) over the premotor and primary motor cortices with the cathode over the cerebellum during treadmill walking. Three montages will be applied over three sessions and compared: anodal tDCS with a small active cathode (4 × 4 cm 2 ); anodal tDCS with a large, functionally inert cathode (10 × 10 cm 2 ); and sham tDCS. The primary outcome measure is gait speed, and secondary outcome measures include gait parameters (temporospatial, segmental, kinematic), the Timed Up and Go test and lower limb muscle activity patterns as measured by electromyography. Discussion: This study will investigate the short-term effects of anodal tDCS over the premotor and primary motor cortices on gait abilities using monopolar and bipolar montages in people with PD. The outcomes will inform future studies aimed at inducing longer-lasting changes in neural excitability and performance using multisession tDCS designs in PD. Trial registration: Australian New Zealand Clinical Trials Registry (ANZCTR), ACTRN12618000063213. Registered on 17 January 2018. Retrospectively registered.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central Ltd.
dc.relation.ispartofpagefrom661:1
dc.relation.ispartofpageto661:12
dc.relation.ispartofissue1
dc.relation.ispartofjournalTrials
dc.relation.ispartofvolume19
dc.subject.fieldofresearchCardiorespiratory Medicine and Haematology
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode1102
dc.subject.fieldofresearchcode1103
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsMedicine, Research & Experimental
dc.subject.keywordsResearch & Experimental Medicine
dc.subject.keywordsParkinson's disease
dc.titleEffects of transcranial direct current stimulation on gait in people with Parkinson's disease: study protocol for a randomized, controlled clinical trial
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationAlizad, V; Meinzer, M; Frossard, L; Polman, R; Smith, S; Kerr, G, Effects of transcranial direct current stimulation on gait in people with Parkinson's disease: study protocol for a randomized, controlled clinical trial, Trials, 2018, 19 (1), pp. 661:1-661:12
dcterms.dateAccepted2018-10-13
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-02-18T05:34:22Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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gro.griffith.authorFrossard, Laurent


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