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dc.contributor.authorLin, Chin
dc.contributor.authorChen, Hsiang-Cheng
dc.contributor.authorFang, Wen-Hui
dc.contributor.authorWang, Chih-Chien
dc.contributor.authorPeng, Yi-Jen
dc.contributor.authorLee, Herng-Sheng
dc.contributor.authorChang, Hung
dc.contributor.authorChu, Chi-Ming
dc.contributor.authorHuang, Guo-Shu
dc.contributor.authorChen, Wei-Teing
dc.contributor.authorTsai, Yu-Jui
dc.contributor.authorLin, Hong-Ling
dc.contributor.authorLin, Fu-Huang
dc.contributor.authorSu, Sui-Lung
dc.date.accessioned2020-02-20T02:58:44Z
dc.date.available2020-02-20T02:58:44Z
dc.date.issued2016
dc.identifier.issn1932-6203
dc.identifier.doi10.1371/journal.pone.0161754
dc.identifier.urihttp://hdl.handle.net/10072/391709
dc.description.abstractBackground: Studies of angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphisms and the risks of knee osteoarthritis (OA) have yielded conflicting results. Objective: To determine the association between ACE I/D and knee OA, we conducted a combined case-control study and meta-analysis. Methods: For the case-control study, 447 knee OA cases and 423 healthy controls were recruited between March 2010 and July 2011. Knee OA cases were defined using the Kellgren-Lawrence grading system, and the ACE I/D genotype was determined using a standard polymerase chain reaction. The association between ACE I/D and knee OA was detected using allele, genotype, dominant, and recessive models. For the meta-analysis, PubMed and Embase databases were systematically searched for prospective observational studies published up until August 2015. Studies of ACE I/D and knee OA with sufficient data were selected. Pooled results were expressed as odds ratios (ORs) with corresponding 95% confidence intervals (CI) for the D versus I allele with regard to knee OA risk. Results: We found no significant association between the D allele and knee OA [OR: 1.09 (95% CI: 0.76-1.89)] in the present case-control study, and the results of other genetic models were also nonsignificant. Five current studies were included, and there were a total of six study populations after including our case-control study (1165 cases and 1029 controls). In the meta-analysis, the allele model also yielded nonsignificant results [OR: 1.37 (95% CI: 0.95-1.99)] and a high heterogeneity (I2: 87.2%). Conclusions: The association between ACE I/D and knee OA tended to yield negative results. High heterogeneity suggests a complex, multifactorial mechanism, and an epistasis analysis of ACE I/D and knee OA should therefore be conducted.
dc.languageEnglish
dc.language.isoeng
dc.publisherPublic Library of Science (PLoS)
dc.relation.ispartofpagefrome0161754
dc.relation.ispartofpagetoe0161754
dc.relation.ispartofissue9
dc.relation.ispartofjournalPLoS One
dc.relation.ispartofvolume11
dc.titleAngiotensin-converting enzyme insertion/deletion polymorphism and susceptibilityto osteoarthritis of the knee: A case-control study and meta-analysis
dc.typeJournal article
dcterms.bibliographicCitationLin, C; Chen, HC; Fang, WH; Wang, CC; Peng, YJ; Lee, HS; Chang, H; Chu, CM; Huang, GS; Chen, WT; Tsai, YJ; Lin, HL; Lin, FH; Su, SL, Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibilityto osteoarthritis of the knee: A case-control study and meta-analysis, PLoS One, 2016, 11 (9), pp. e0161754-e0161754
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-02-20T02:55:36Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2016 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
gro.hasfulltextFull Text
gro.griffith.authorChu, Cordia M.


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