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dc.contributor.authorTartaglia, Gianluca M
dc.contributor.authorTadakamadla, Santosh Kumar
dc.contributor.authorConnelly, Stephen Thaddeus
dc.contributor.authorSforza, Chiarella
dc.contributor.authorMartín, Conchita
dc.date.accessioned2020-02-20T02:59:50Z
dc.date.available2020-02-20T02:59:50Z
dc.date.issued2019
dc.identifier.issn2042-0986
dc.identifier.doi10.1177/2042098619854881
dc.identifier.urihttp://hdl.handle.net/10072/391710
dc.description.abstractBackground: Poor oral hygiene is strongly associated with oral and systemic diseases. Alongside mechanical tooth cleaning, the adjunctive use of mouthrinses has been widely advocated. Although research on the efficacy of various mouthrinse formulations is very active, there are a lack of conclusive data regarding their adverse effects. Methods: We undertook a systematic review in accordance wih PRISMA guidelines of electronic databases of clinical trials of any duration with daily home use of mouthwashes, presenting clinical and subjective side effects (PROSPERO registration: CRD42016054037). Results: After evaluating 614 titles and abstracts, 154 studies were selected for full-text analysis; 85 final papers were included. Based on the active ingredient in the test product, nine categories were created: cetyl pyridinium chloride, essential oils, chlorhexidine, triclosan, natural products, diclofenac, fluorides, delmopinol, and miscellaneous active substances. Most of the studies were of short duration (less than 6 months) with a defective ‘methods’ description; the reporting of adverse events often being overlooked. Both local morphological (oral mucosa and dental-crown staining, mucosal lesions) and functional (taste modifications, abnormal oral sensation) alterations were reported. Tooth staining was the most commonly listed adverse event, but it was quantitatively assessed only in a very small number of papers; most studies relied on patient reports. Staining was time associated; the longer the study, the higher its reported incidence and severity. Conclusions: The reduced report of side effects may partly be due to a lack of an objective measure and lack of general guidelines that demand studies report their adverse events. The most frequently reported adverse effect was teeth staining. As in most studies, the effect was associated with trial duration; clinical trials should be of sufficient duration. New investigations meeting the suggested criteria of a minimal duration of 6 months should be planned.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSAGE Publications
dc.relation.ispartofjournalTherapeutic Advances in Drug Safety
dc.relation.ispartofvolume10
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3214
dc.titleAdverse events associated with home use of mouthrinses: a systematic review
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationTartaglia, GM; Tadakamadla, SK; Connelly, ST; Sforza, C; Martín, C, Adverse events associated with home use of mouthrinses: a systematic review, Therapeutic Advances in Drug Safety, 2019, 10
dcterms.licensehttps://creativecommons.org/licenses/by-nc/4.0/
dc.date.updated2020-02-19T05:45:33Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
gro.hasfulltextFull Text
gro.griffith.authorTadakamadla, Santosh Kumar


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