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dc.contributor.authorSantarelli, Lory
dc.contributor.authorGaetani, Simona
dc.contributor.authorMonaco, Federica
dc.contributor.authorBracci, Massimo
dc.contributor.authorValentino, Matteo
dc.contributor.authorAmati, Monica
dc.contributor.authorRubini, Corrado
dc.contributor.authorSabbatini, Armando
dc.contributor.authorPasquini, Ernesto
dc.contributor.authorZanotta, Nunzia
dc.contributor.authorComar, Manola
dc.contributor.authorNeuzil, Jiri
dc.contributor.authorTomasetti, Marco
dc.contributor.authorBovenzi, Massimo
dc.description.abstractBACKGROUND: Altered miRNA expression is an early event upon exposure to occupational/environmental carcinogens; thus, identification of a novel asbestos-related profile of miRNAs able to distinguish asbestos-induced cancer from cancer with different etiology can be useful for diagnosis. We therefore performed a study to identify miRNAs associated with asbestos-induced malignancies. METHODS: Four groups of patients were included in the study, including patients with asbestos-related (NSCLCAsb) and asbestos-unrelated non-small cell lung cancer (NSCLC) or with malignant pleural mesothelioma (MPM), and disease-free subjects (CTRL). The selected miRNAs were evaluated in asbestos-exposed population. RESULTS: Four serum miRNAs, that is miR-126, miR-205, miR-222, and miR-520g, were found to be implicated in asbestos-related malignant diseases. Notably, increased expression of miR-126 and miR-222 were found in asbestos-exposed subjects, and both miRNAs are involved in major pathways linked to cancer development. Epigenetic changes and cancer-stroma cross-talk could induce repression of miR-126 to facilitate tumor formation, angiogenesis, and invasion. CONCLUSIONS: This study indicates that miRNAs are potentially involved in asbestos-related malignancies, and their expression outlines mechanism(s) whereby miRNAs may be involved in an asbestos-induced pathogenesis. IMPACT: The discovery of a miRNA panel for asbestos-related malignancies would impact on occupational compensation and may be utilized for screening asbestos-exposed populations.
dc.publisherAmerican Association for Cancer Research
dc.relation.ispartofjournalCancer Epidemiology, Biomarkers & Prevention
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsPublic, Environmental & Occupational Health
dc.titleFour-miRNA Signature to Identify Asbestos-Related Lung Malignancies
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSantarelli, L; Gaetani, S; Monaco, F; Bracci, M; Valentino, M; Amati, M; Rubini, C; Sabbatini, A; Pasquini, E; Zanotta, N; Comar, M; Neuzil, J; Tomasetti, M; Bovenzi, M, Four-miRNA Signature to Identify Asbestos-Related Lung Malignancies, Cancer Epidemiology, Biomarkers & Prevention, 2019, 28 (1), pp. 119-126
gro.hasfulltextNo Full Text
gro.griffith.authorNeuzil, Jiri

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