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dc.contributor.authorJames, Kylie R
dc.contributor.authorSoon, Megan SF
dc.contributor.authorSebina, Ismail
dc.contributor.authorFernandez-Ruiz, Daniel
dc.contributor.authorDavey, Gayle
dc.contributor.authorLiligeto, Urijah N
dc.contributor.authorNair, Arya Sheela
dc.contributor.authorFogg, Lily G
dc.contributor.authorEdwards, Chelsea L
dc.contributor.authorBest, Shannon E
dc.contributor.authorLansink, Lianne IM
dc.contributor.authorSchroder, Kate
dc.contributor.authorWilson, Jane AC
dc.contributor.authorEngwerda, Christian R
dc.contributor.authoret al.
dc.description.abstractDifferentiation of CD4+ Th cells is critical for immunity to malaria. Several innate immune signaling pathways have been implicated in the detection of blood-stage Plasmodium parasites, yet their influence over Th cell immunity remains unclear. In this study, we used Plasmodium-reactive TCR transgenic CD4+ T cells, termed PbTII cells, during nonlethal P. chabaudi chabaudi AS and P. yoelii 17XNL infection in mice, to examine Th cell development in vivo. We found no role for caspase1/11, stimulator of IFN genes, or mitochondrial antiviral-signaling protein, and only modest roles for MyD88 and TRIF-dependent signaling in controlling PbTII cell expansion. In contrast, IFN regulatory factor 3 (IRF3) was important for supporting PbTII expansion, promoting Th1 over T follicular helper (Tfh) differentiation, and controlling parasites during the first week of infection. IRF3 was not required for early priming by conventional dendritic cells, but was essential for promoting CXCL9 and MHC class II expression by inflammatory monocytes that supported PbTII responses in the spleen. Thereafter, IRF3-deficiency boosted Tfh responses, germinal center B cell and memory B cell development, parasite-specific Ab production, and resolution of infection. We also noted a B cell-intrinsic role for IRF3 in regulating humoral immune responses. Thus, we revealed roles for IRF3 in balancing Th1- and Tfh-dependent immunity during nonlethal infection with blood-stage Plasmodium parasites.
dc.publisherAmerican Association of Immunologists
dc.relation.ispartofjournalThe Journal of Immunology
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsDENDRITIC CELLS
dc.titleIFN Regulatory Factor 3 Balances Th1 and T Follicular Helper Immunity during Nonlethal Blood-Stage Plasmodium Infection
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationJames, KR; Soon, MSF; Sebina, I; Fernandez-Ruiz, D; Davey, G; Liligeto, UN; Nair, AS; Fogg, LG; Edwards, CL; Best, SE; Lansink, LIM; Schroder, K; Wilson, JAC; Austin, R; Suhrbier, A; Lane, SW; Hill, GR; Engwerda, CR; Heath, WR; Haque, A, IFN Regulatory Factor 3 Balances Th1 and T Follicular Helper Immunity during Nonlethal Blood-Stage Plasmodium Infection,The Journal of Immunology, 2018, 200 (4), pp. 1443-1456
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
gro.hasfulltextNo Full Text
gro.griffith.authorEngwerda, Christian R.

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