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dc.contributor.authorPrasad, Karthika
dc.contributor.authorLekshmi, GS
dc.contributor.authorOstrikov, Kola
dc.contributor.authorLussini, Vanessa
dc.contributor.authorBlinco, James
dc.contributor.authorMohandas, Mandhakini
dc.contributor.authorVasilev, Krasimir
dc.contributor.authorBottle, Steven
dc.contributor.authorBazaka, Kateryna
dc.contributor.authorOstrikov, Kostya
dc.date.accessioned2020-02-24T01:41:27Z
dc.date.available2020-02-24T01:41:27Z
dc.date.issued2017
dc.identifier.issn2045-2322
dc.identifier.doi10.1038/s41598-017-01669-5
dc.identifier.urihttp://hdl.handle.net/10072/391814
dc.description.abstractReduced graphene oxide (rGO) is a promising antibacterial material, the efficacy of which can be further enhanced by the addition of silver nanoparticles (nAg). In this study, the mechanisms of antibacterial activity of rGO–nAg nanocomposite against several important human pathogenic multi-drug resistant bacteria, namely Gram-positive coccal Staphylococcus aureus and Gram-negative rod-shaped Escherichia coli and Proteus mirabilis are investigated. At the same concentration (100 µg/ml), rGO–nAg nanocomposite was significantly more effective against all three pathogens than either rGO or nAg. The nanocomposite was equally active against P. mirabilis and S. aureus as systemic antibiotic nitrofurantoin, and significantly more effective against E. coli. Importantly, the inhibition was much faster in the case of rGO–nAg nanocomposite compared to nitrofurantoin, attributed to the synergistic effects of rGO–nAg mediated contact killing and oxidative stress. This study may provide new insights for the better understanding of antibacterial actions of rGO–nAg nanocomposite and for the better designing of graphene-based antibiotics or other biomedical applications.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofissue1
dc.relation.ispartofjournalScientific Reports
dc.relation.ispartofvolume7
dc.subject.fieldofresearchNanobiotechnology
dc.subject.fieldofresearchcode310607
dc.subject.keywordsScience & Technology
dc.subject.keywordsMultidisciplinary Sciences
dc.subject.keywordsScience & Technology - Other Topics
dc.subject.keywordsANTIBACTERIAL ACTIVITY
dc.subject.keywordsANTIMICROBIAL ACTIVITY
dc.titleSynergic bactericidal effects of reduced graphene oxide and silver nanoparticles against Gram-positive and Gram-negative bacteria
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationPrasad, K; Lekshmi, GS; Ostrikov, K; Lussini, V; Blinco, J; Mohandas, M; Vasilev, K; Bottle, S; Bazaka, K; Ostrikov, K, Synergic bactericidal effects of reduced graphene oxide and silver nanoparticles against Gram-positive and Gram-negative bacteria, Scientific Reports, 2017, 7 (1)
dcterms.dateAccepted2017-04-03
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-02-24T01:37:12Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2017 The Authors. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
gro.hasfulltextFull Text
gro.griffith.authorOstrikov, Ken


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