dc.contributor.author | Donato, Peter | |
dc.contributor.author | Roberts, Matthew J | |
dc.contributor.author | Morton, Andrew | |
dc.contributor.author | Kyle, Samuel | |
dc.contributor.author | Coughlin, Geoff | |
dc.contributor.author | Esler, Rachel | |
dc.contributor.author | Dunglison, Nigel | |
dc.contributor.author | Gardiner, Robert A | |
dc.contributor.author | Yaxley, John | |
dc.date.accessioned | 2020-02-24T03:53:42Z | |
dc.date.available | 2020-02-24T03:53:42Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1619-7070 | |
dc.identifier.doi | 10.1007/s00259-018-4160-7 | |
dc.identifier.uri | http://hdl.handle.net/10072/391823 | |
dc.description.abstract | PURPOSE: Positron emission tomography (PET) for prostate-specific membrane antigen (PSMA) represents a promising method for prostate cancer diagnosis and staging. Comparisons of PSMA-based tumour characterisation to multiparametric MRI (mpMRI) are limited, hence this study sought to compare the diagnostic accuracy of 68Ga-PSMA PET/CT to mpMRI against radical prostatectomy (RP) whole gland histopathology. METHODS: A retrospective cohort study of consecutive patients who underwent pre-operative mpMRI and 68Ga-PSMA PET/CT followed by a RP was performed. Standard clinical parameters were collected. "Per patient" and "per lesion" analyses for image-based detection according to RP histopathology were described using sensitivity, specificity and other measures of diagnostic accuracy. RESULTS: Fifty-eight patients (median age 65.5 years, median PSA 7.35 ng/mL) underwent RP, resulting in a high-risk cohort (≥pT3 69%). Sensitivities for identification of index lesion, bilateral and multifocal disease were 90%, 21%, 19% for mpMRI and 93%, 42%, 34% for 68Ga-PSMA PET/CT. Histology analyses revealed 88 cancer foci of Gleason grades 3 + 3 (4%), 3 + 4 (64%), 4 + 3 (19%), 4 + 4 (3%) and ≥ 4 + 5 (10%), of which 68Ga-PSMA PET/CT correctly detected more foci (78%, AUC 0.817) than mpMRI (69%, AUC 0.729). CONCLUSIONS: 68Ga-PSMA PET/CT may better reflect RP histopathology compared to mpMRI when considering multifocal and bilateral disease. These findings may influence surgical planning, targeted biopsy and focal therapy strategies and require further research. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Springer | |
dc.relation.ispartofpagefrom | 20 | |
dc.relation.ispartofpageto | 30 | |
dc.relation.ispartofissue | 1 | |
dc.relation.ispartofjournal | European Journal of Nuclear Medicine and Molecular Imaging | |
dc.relation.ispartofvolume | 46 | |
dc.subject.fieldofresearch | Other physical sciences | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearchcode | 5199 | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.keywords | Science & Technology | |
dc.subject.keywords | Life Sciences & Biomedicine | |
dc.subject.keywords | Radiology, Nuclear Medicine & Medical Imaging | |
dc.subject.keywords | Prostatic neoplasms | |
dc.subject.keywords | Positron-emission tomography | |
dc.title | Improved specificity with Ga-68 PSMA PET/CT to detect clinically significant lesions "invisible" on multiparametric MRI of the prostate: a single institution comparative analysis with radical prostatectomy histology | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Donato, P; Roberts, MJ; Morton, A; Kyle, S; Coughlin, G; Esler, R; Dunglison, N; Gardiner, RA; Yaxley, J, Improved specificity with Ga-68 PSMA PET/CT to detect clinically significant lesions "invisible" on multiparametric MRI of the prostate: a single institution comparative analysis with radical prostatectomy histology, European Journal of Nuclear Medicine and Molecular Imaging , 2019, 46 (1), pp. 20-30 | |
dcterms.dateAccepted | 2018-09-05 | |
dc.date.updated | 2020-02-24T03:52:26Z | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Gardiner, Robert A. | |