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dc.contributor.authorRahmanzadeh-Shahi, Soheila
dc.contributor.authorGolshiri-Isfahani, Ali
dc.contributor.authorFathollahi, Mahmood Sheikh
dc.contributor.authorRezayati, Mohammadtaghi
dc.contributor.authorBahramabadi, Reza
dc.contributor.authorAfrooz, Mohammadreza
dc.contributor.authorAsadikaram, Gholamreza
dc.contributor.authorKennedy, Derek
dc.contributor.authorArababadi, Mohammad Kazemi
dc.date.accessioned2020-02-24T04:51:32Z
dc.date.available2020-02-24T04:51:32Z
dc.date.issued2018
dc.identifier.issn0007-5027en_US
dc.identifier.doi10.1093/labmed/lmy017en_US
dc.identifier.urihttp://hdl.handle.net/10072/391838
dc.description.abstractObjective: To evaluate the serum levels of interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α, tumor growth factor (TGF)-β, endothelin, and immunoglobulin (Ig)E in patients with idiopathic epistaxis, compared with healthy control individuals. Methods: Serum levels of IL-6, IL-8, TNF-α, TGF-β, endothelin, and IgE were evaluated in 110 patients with idiopathic epistaxis and 100 healthy controls using the enzyme-linked immunosorbent assay (ELISA) technique. Results: Serum levels of IL-6 (P <.001) and TGF-β (P = .001) were significantly increased in patients with idiopathic epistaxis, compared with controls. TNF-α serum levels were significantly increased in male patients, compared with female patients (P = .053). We observed decreased antihistamine levels and increased expression of TGF-β (P = .02) and TNF-α (P = .02), respectively. Conclusions: IL-6 and TGF-β appear to participate in the pathogenesis of idiopathic epistaxis. TNF-α may be considered a risk factor for male patients in developing epistaxis. Antihistamines may inhibit angiogenesis by decreasing expression of TGF-β and increasing expression of TNF-α.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.language.isoeng
dc.publisherOxford University Pressen_US
dc.relation.ispartofpagefrom329en_US
dc.relation.ispartofpageto341en_US
dc.relation.ispartofissue4en_US
dc.relation.ispartofjournalLaboratory Medicineen_US
dc.relation.ispartofvolume49en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsMedical Laboratory Technologyen_US
dc.subject.keywordscytokineen_US
dc.subject.keywordsendothelinen_US
dc.titleInterleukin-6 and Tumor Growth Factor–β are Risk Factors for Idiopathic Epistaxisen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationRahmanzadeh-Shahi, S; Golshiri-Isfahani, A; Fathollahi, MS; Rezayati, M; Bahramabadi, R; Afrooz, M; Asadikaram, G; Kennedy, D; Arababadi, MK, Interleukin-6 and Tumor Growth Factor–β are Risk Factors for Idiopathic Epistaxis, Laboratory Medicine, 2018, 49 (4), pp. 329-341en_US
dc.date.updated2020-02-24T04:49:22Z
gro.hasfulltextNo Full Text
gro.griffith.authorKennedy, Derek D.


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