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dc.contributor.authorZhao, Qianbin
dc.contributor.authorZhang, Jun
dc.contributor.authorYan, Sheng
dc.contributor.authorYuan, Dan
dc.contributor.authorDu, Haiping
dc.contributor.authorAlici, Gursel
dc.contributor.authorLi, Weihua
dc.date.accessioned2020-02-25T00:10:31Z
dc.date.available2020-02-25T00:10:31Z
dc.date.issued2017
dc.identifier.issn2045-2322
dc.identifier.doi10.1038/srep41153
dc.identifier.urihttp://hdl.handle.net/10072/391856
dc.description.abstractSheathless particle focusing which utilises the secondary flow with a high throughput has great potential for use in microfluidic applications. In this work, an innovative particle focusing method was proposed. This method makes use of a mechanism that takes advantage of secondary flow and inertial migration. The device was a straight channel with arrays of arc-shaped grooves on the top surface. First, the mechanism and expected focusing phenomenon are explained using numerical simulation of the flow field and force balance. A simulation of particle trajectories was conducted as a reference, and then a series of experiments was designed and the effects of changes in particle size, flow rate and quantity of the groove structure were discussed. The microscopic images show that this particle focusing method performed well for different size particles, and the results agreed well with the theory and simulated results. Finally, the channel successfully concentrated Jurkat cells, which showed a good compatibility in the biological assay field. In this work, the arc-shaped groove channel was demonstrated to have the ability to achieve high-throughput, sheathless and three-dimensional particle focusing with simple operations.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherNature Publishing Group
dc.relation.ispartofissue1
dc.relation.ispartofjournalScientific Reports
dc.relation.ispartofvolume7
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchOther Physical Sciences
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode0299
dc.subject.keywordsScience & Technology
dc.subject.keywordsMultidisciplinary Sciences
dc.subject.keywordsScience & Technology - Other Topics
dc.subject.keywordsCIRCULATING TUMOR-CELLS
dc.subject.keywordsSURFACE ACOUSTIC-WAVES
dc.titleHigh-throughput sheathless and three-dimensional microparticle focusing using a microchannel with arc-shaped groove arrays
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationZhao, Q; Zhang, J; Yan, S; Yuan, D; Du, H; Alici, G; Li, W, High-throughput sheathless and three-dimensional microparticle focusing using a microchannel with arc-shaped groove arrays, Scientific Reports, 2017, 7 (1)
dcterms.dateAccepted2016-12-14
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-02-25T00:08:11Z
dc.description.versionPublished
gro.rights.copyright© The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
gro.hasfulltextFull Text
gro.griffith.authorZhang, Jun


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