Optimizing Energy Transfer in Nanostructures Enables In Vivo Cancer Lesion Tracking via Near-Infrared Excited Hypoxia Imaging
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Author(s)
Li, Yantao
Liu, Jiaming
Wang, Zuochao
Jin, Jun
Liu, Yaling
Chen, Chunying
Tang, Zhiyong
Griffith University Author(s)
Year published
2020
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To explore highly sensitive and low‐toxicity techniques for tracking and evaluation of non‐small‐cell lung cancer (NSCLC), one of the most mortal tumors in the world, it is utterly imperative for doctors to select the appropriate treatment strategies. Herein, developing near‐infrared (NIR) excited nanosensors, in which the donor and acceptor pairs within a biological metal–organic framework (bio‐MOF) matrix are precisely controlled to rationalize upconversion Förster resonance energy transfer (FRET), is suggested for detecting the O2 concentration inside tumors with reduced signal disturbance and health detriment. Under NIR ...
View more >To explore highly sensitive and low‐toxicity techniques for tracking and evaluation of non‐small‐cell lung cancer (NSCLC), one of the most mortal tumors in the world, it is utterly imperative for doctors to select the appropriate treatment strategies. Herein, developing near‐infrared (NIR) excited nanosensors, in which the donor and acceptor pairs within a biological metal–organic framework (bio‐MOF) matrix are precisely controlled to rationalize upconversion Förster resonance energy transfer (FRET), is suggested for detecting the O2 concentration inside tumors with reduced signal disturbance and health detriment. Under NIR excitation, as‐fabricated core/satellite nanosensors exhibit much improved FRET efficiency and reversible hypoxic response with high sensitivity, which are effective both in vitro and in vivo (zebrafish) for cycling normoxia–hypoxia imaging. Significantly, combined with a reliable preclinical genetically engineered murine model, such nanosensors successfully realize tracking of in vivo NSCLC lesions upon clear and gradient hypoxia signals without apparent long‐term biotoxicity, illustrating their exciting potential for efficient NSCLC evaluation and prognosis.
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View more >To explore highly sensitive and low‐toxicity techniques for tracking and evaluation of non‐small‐cell lung cancer (NSCLC), one of the most mortal tumors in the world, it is utterly imperative for doctors to select the appropriate treatment strategies. Herein, developing near‐infrared (NIR) excited nanosensors, in which the donor and acceptor pairs within a biological metal–organic framework (bio‐MOF) matrix are precisely controlled to rationalize upconversion Förster resonance energy transfer (FRET), is suggested for detecting the O2 concentration inside tumors with reduced signal disturbance and health detriment. Under NIR excitation, as‐fabricated core/satellite nanosensors exhibit much improved FRET efficiency and reversible hypoxic response with high sensitivity, which are effective both in vitro and in vivo (zebrafish) for cycling normoxia–hypoxia imaging. Significantly, combined with a reliable preclinical genetically engineered murine model, such nanosensors successfully realize tracking of in vivo NSCLC lesions upon clear and gradient hypoxia signals without apparent long‐term biotoxicity, illustrating their exciting potential for efficient NSCLC evaluation and prognosis.
View less >
Journal Title
Advanced Materials
Copyright Statement
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Optimizing Energy Transfer in Nanostructures Enables In Vivo Cancer Lesion Tracking via Near-Infrared Excited Hypoxia Imaging, Advanced Materials, which has been published in final form at 10.1002/adma.201907718. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
Note
This publication has been entered into Griffith Research Online as an Advanced Online Version.
Subject
Physical sciences
Chemical sciences
Engineering
cancer lesion tracking
core/satellite nanostructures
hypoxia imaging
metal-organic frameworks
near-infrared excitation