Show simple item record

dc.contributor.authorMa, Linlin
dc.contributor.authorLee, Bo Hyun
dc.contributor.authorClifton, Heather
dc.contributor.authorSchaefer, Saul
dc.contributor.authorZheng, Jie
dc.date.accessioned2020-02-27T04:27:18Z
dc.date.available2020-02-27T04:27:18Z
dc.date.issued2015
dc.identifier.issn2045-2322
dc.identifier.doi10.1038/srep08906
dc.identifier.urihttp://hdl.handle.net/10072/391976
dc.description.abstractNicotinic acid (NA, a.k.a. vitamin B3 or niacin) can reduce blood cholesterol and low-density lipoproteins whereas increase high-density lipoproteins. However, when NA is used to treat dyslipidemias, it causes a strong side effect of cutaneous vasodilation, commonly called flushing. A recent study showed that NA may cause flushing by lowering activation threshold temperature of the heat-sensitive capsaicin receptor TRPV1 ion channel, leading to its activation at body temperature. The finding calls into question whether NA might also interact with the homologous heat-sensitive TRPV2–4 channels, particularly given that TRPV3 and TRPV4 are abundantly expressed in keratinocytes of the skin where much of the flushing response occurs. We found that NA indeed potentiated TRPV3 while inhibited TRPV2 and TRPV4. Consistent with these gating effects, NA lowered the heat-activation threshold of TRPV3 but elevated that of TRPV4. We further found that activity of TRPV1 was substantially prolonged by extracellular NA, which may further enhance the direct activation effect. Consistent with the broad gating effect on TRPV1–4 channels, evidence from the present study hints that NA may share the same activation pathway as 2-aminoethoxydiphenyl borate (2-APB), a common agonist for these TRPV channels. These findings shed new light on the molecular mechanism underlying NA regulation of TRPV channels.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherNature Publishing Group
dc.relation.ispartofissue1
dc.relation.ispartofjournalScientific Reports
dc.relation.ispartofvolume5
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchOther Physical Sciences
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode0299
dc.subject.keywordsScience & Technology
dc.subject.keywordsMultidisciplinary Sciences
dc.subject.keywordsScience & Technology - Other Topics
dc.subject.keywordsEXTENDED-RELEASE NIACIN
dc.subject.keywordsCAPSAICIN RECEPTOR
dc.titleNicotinic Acid is a Common Regulator of Heat-Sensing TRPV1-4 Ion Channels
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMa, L; Lee, BH; Clifton, H; Schaefer, S; Zheng, J, Nicotinic Acid is a Common Regulator of Heat-Sensing TRPV1-4 Ion Channels, Scientific Reports, 2015, 5 (1)
dcterms.dateAccepted2015-02-05
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-02-27T04:25:23Z
dc.description.versionPublished
gro.rights.copyright© The Author(s) 2015. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
gro.hasfulltextFull Text
gro.griffith.authorMa, Linlin


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record