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dc.contributor.authorGane, Elise M
dc.contributor.authorSteele, Megan L
dc.contributor.authorJanda, Monika
dc.contributor.authorWard, Leigh C
dc.contributor.authorReul-Hirche, Hildegard
dc.contributor.authorCarter, Jonathan
dc.contributor.authorQuinn, Michael
dc.contributor.authorObermair, Andreas
dc.contributor.authorHayes, Sandra C
dc.date.accessioned2020-03-05T05:41:38Z
dc.date.available2020-03-05T05:41:38Z
dc.date.issued2018
dc.identifier.issn2168-3808
dc.identifier.doi10.1097/01.REO.0000000000000102
dc.identifier.urihttp://hdl.handle.net/10072/392127
dc.description.abstractBackground: Incidence of lymphedema appears to be higher in women with vulvar/vaginal cancer than in those with other forms of gynecological cancer. The objective of this work was to determine the point prevalence and incidence of lymphedema in women with vulvar/vaginal cancer and to describe symptom burden and quality of life (QOL). Methods: Prospective longitudinal cohort study conducted in Brisbane, Australia, including adult women with newly diagnosed vulvar/vaginal cancer. The primary outcome was selfreported swelling of the legs, vulvar area, or pelvis/abdomen or a clinical diagnosis of lymphedema. Severity of associated symptoms and QOL (Functional Assessment of Cancer Therapy-General) were also reported. Assessments were conducted over 2 years. Results: All participants (vulvar: n = 20; vaginal: n = 2; mean [SD] age = 57 [12] years) received surgical treatment, and 8 (36%) also received adjuvant therapy. By 24 months postdiagnosis, only 2 (9%) women had no evidence of lymphedema; all others self-reported swelling (n = 10; 45%), had a clinical diagnosis (n = 1; 5%), or both (n = 9; 41%). Three or more symptoms of moderate or greater intensity were reported by 7 (44%) women at 2 years. The presence of lower limb symptoms (including mild intensity) was associated with reduced QOL (any symptom: QOL estimate = -13.29; 95% CI, -19.30 to -7.27; P < .001). Limitations: Small sample size limits interpretation of findings. Conclusion: These findings demonstrate that the majority of women receiving treatment of vulvar/vaginal cancer experience lymphedema and symptoms of swelling are associated with lower QOL. Monitoring of swelling via patient self-report may identify women at risk of low QOL outcomes after treatment of vulvar/vaginal cancer.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofpagefrom48
dc.relation.ispartofpageto55
dc.relation.ispartofissue1
dc.relation.ispartofjournalRehabilitation Oncology
dc.relation.ispartofvolume36
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode1112
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsOncology
dc.subject.keywordsepidemiology
dc.subject.keywordslymphedema
dc.titleThe Prevalence, Incidence, and Quality-of-Life Impact of Lymphedema After Treatment for Vulvar or Vaginal Cancer
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationGane, EM; Steele, ML; Janda, M; Ward, LC; Reul-Hirche, H; Carter, J; Quinn, M; Obermair, A; Hayes, SC, The Prevalence, Incidence, and Quality-of-Life Impact of Lymphedema After Treatment for Vulvar or Vaginal Cancer, Rehabilitation Oncology, 2018, 36 (1), pp. 48-55
dc.date.updated2020-03-05T05:39:56Z
gro.hasfulltextNo Full Text
gro.griffith.authorHayes, Sandi C.
gro.griffith.authorReul-Hirche, Hildegard M.


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