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dc.contributor.authorBoutrus, M
dc.contributor.authorMaybery, MT
dc.contributor.authorAlvares, GA
dc.contributor.authorTan, DW
dc.contributor.authorVarcin, KJ
dc.contributor.authorWhitehouse, AJO
dc.date.accessioned2020-03-16T07:21:00Z
dc.date.available2020-03-16T07:21:00Z
dc.date.issued2017
dc.identifier.issn1939-3792
dc.identifier.doi10.1002/aur.1824
dc.identifier.urihttp://hdl.handle.net/10072/392350
dc.description.abstractAtypical facial characteristics have been observed in many disorders associated with developmental disability. While autism spectrum conditions (ASC) have not previously been thought to be associated with a distinct facial phenotype, an emerging research literature is casting doubt on this assumption. The identification of differences in the facial phenotype of individuals with ASC may contribute to efforts to promote early identification of the condition and help elucidate etiological pathways. With the aim of identifying facial phenotypes associated with ASC, this commentary evaluated facial features purported to distinguish ASC from typical development. Although there is little consensus across the reviewed studies for the majority of facial characteristics described, preliminary evidence suggests increased facial asymmetry may be more common in ASC. There is also evidence to suggest that there are morphologically distinct subgroups within ASC that correspond with different cognitive and behavioral symptomatology. However, in light of the various inconsistencies in the reported literature, and based on an accumulating understanding of etiological pathways proposed to be associated with ASC, we propose an alternative paradigm for investigating facial phenotypes in ASC. A series of studies are outlined to demonstrate the promise of a research program that has taken a hypothesis-driven approach to examine facial phenotypes associated with increased exposure to prenatal testosterone and to ASC. Autism Res 2017, 10: 1910–1918. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary: This commentary reviewed studies that found differences in the facial features of individuals with autism spectrum conditions (ASC) compared to typically developing individuals. While there is little agreement between studies, there is some support for asymmetrical facial features associated with ASC, and preliminary evidence that particular facial features relate to specific patterns of cognitive and behavioral symptoms. However, in light of inconsistencies between studies and based on accumulating understanding of etiological pathways, we propose an alternative approach to investigating facial differences in ASC.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofpagefrom1910
dc.relation.ispartofpageto1918
dc.relation.ispartofissue12
dc.relation.ispartofjournalAutism Research
dc.relation.ispartofvolume10
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1701
dc.subject.keywordsautism
dc.subject.keywordsfacial phenotype
dc.subject.keywordsmorphology
dc.subject.keywordsneurodevelopment
dc.subject.keywordssubgroups
dc.titleInvestigating facial phenotype in autism spectrum conditions: The importance of a hypothesis driven approach
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBoutrus, M; Maybery, MT; Alvares, GA; Tan, DW; Varcin, KJ; Whitehouse, AJO, Investigating facial phenotype in autism spectrum conditions: The importance of a hypothesis driven approach, Autism Research, 2017, 10 (12), pp. 1910-1918
dcterms.dateAccepted2017-05-23
dc.date.updated2020-03-16T07:19:44Z
gro.hasfulltextNo Full Text
gro.griffith.authorVarcin, Kandice J.


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