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dc.contributor.authorHsu, Jen-Te
dc.contributor.authorChung, Chang-Min
dc.contributor.authorChu, Chi-Ming
dc.contributor.authorLin, Yu-Shen
dc.contributor.authorPan, Kuo-Li
dc.contributor.authorChang, Jung-Jung
dc.contributor.authorWang, Po-Chang
dc.contributor.authorChang, Shih-Tai
dc.contributor.authorYang, Teng-Yao
dc.contributor.authorJang, Shih-Jung
dc.contributor.authorYang, Tsung-Han
dc.contributor.authorHsiao, Ju-Feng
dc.date.accessioned2020-03-18T02:09:33Z
dc.date.available2020-03-18T02:09:33Z
dc.date.issued2017
dc.identifier.issn1449-1907
dc.identifier.doi10.7150/ijms.17145
dc.identifier.urihttp://hdl.handle.net/10072/392415
dc.description.abstractBackground: Previous studies reported that patients who had an acute myocardial infarction (AMI) have found that measuring B-type natriuretic peptide (BNP) during the subacute phase of left ventricular (LV) remodeling can predict the possible course of LV remodeling. This study assessed the use of serial BNP serum levels combined with early creatine kinase-MB (CK-MB) to predict the development of significant LV remodeling in AMI patients. Methods: Nighty-seven patients with new onset AMI were assessed using serial echocardiographic studies and serial measurements of BNP levels, both performed on day-2 (BNP1), day-7 (BNP2), day-90 (BNP3), and day-180 (BNP4) after admission. LV remodeling was defined as >20% increase in biplane LV end-diastolic volume on day-180 compared to baseline (day-2). Results: Patients were divided into LV remodeling [LVR(+)] and non LV remodeling [LVR(-)] groups. No first-week BNP level was found to predict remodeling. However, the two groups had significantly different day-90 BNP level (208.1 ± 263.7 pg/ml vs. 82.4 ± 153.7 pg/ml, P = 0.039) and significantly different 3-month BNP decrease ratios (RBNP13) (14.4 ± 92.2% vs. 69.4 ± 25.9%, P < 0.001). The appropriate cut-off value for RBNP13 was 53.2% (AUC = 0.764, P < 0.001). Early peak CK-MB (cut-off 48.2 ng/ml; AUC = 0.672; P = 0.014) was another independent predictor of remodeling. Additionally, combining peak CK-MB and RBNP13 offered an excellent discrimination for half-year remodeling when assessed by ROC curve (AUC = 0.818, P < 0.001). Conclusion: RBNP13 is a significant independent predictor of 6-month LV remodeling. The early peak CK-MB additionally offered an incremental power to the predictions derived from serial BNP examinations.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherIvyspring International Publisher
dc.relation.ispartofpagefrom75
dc.relation.ispartofpageto85
dc.relation.ispartofissue1
dc.relation.ispartofjournalInternational Journal of Medical Sciences
dc.relation.ispartofvolume14
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode11
dc.subject.keywordsB-type Natriuretic Peptide (BNP)
dc.subject.keywordsBNP decrease ratio
dc.subject.keywordsacute myocardial infarction (AMI)
dc.subject.keywordsleft ventricular remodeling
dc.subject.keywordspeak creatine kinase-MB.
dc.titlePredictors of left ventricle remodeling: Combined plasma B-type natriuretic peptide decreasing ratio and peak creatine kinase-MB
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationHsu, JT; Chung, CM; Chu, CM; Lin, YS; Pan, KL; Chang, JJ; Wang, PC; Chang, ST; Yang, TY; Jang, SJ; Yang, TH; Hsiao, JF, Predictors of left ventricle remodeling: Combined plasma B-type natriuretic peptide decreasing ratio and peak creatine kinase-MB, International Journal of Medical Sciences, 2017, 14 (1), pp. 75-85
dcterms.dateAccepted2016-11-24
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-03-18T02:07:28Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
gro.hasfulltextFull Text
gro.griffith.authorChu, Cordia M.


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