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dc.contributor.authorEarley, Daniel F
dc.contributor.authorBailly, Benjamin
dc.contributor.authorMaggioni, Andrea
dc.contributor.authorKundur, Avinash R
dc.contributor.authorThomson, Robin J
dc.contributor.authorChang, Chih-Wei
dc.contributor.authorvon Itzstein, Mark
dc.date.accessioned2020-03-19T01:10:09Z
dc.date.available2020-03-19T01:10:09Z
dc.date.issued2019
dc.identifier.issn2373-8227
dc.identifier.doi10.1021/acsinfecdis.9b00070
dc.identifier.urihttp://hdl.handle.net/10072/392446
dc.description.abstractEnterovirus 71 (EV71) is a major etiological agent of hand, foot, and mouth disease, for which there is no antiviral therapy. We have developed densely sulfated disaccharide heparan sulfate (HS) analogues that are potent small molecule inhibitors of EV71 infection, binding to the viral capsid and acting as decoy receptors to block early events of virus replication. The simplified structures, more potent than defined HS disaccharides and with no significant anticoagulant activity, offer promise as anti-EV71 agents.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.ispartofpagefrom1708
dc.relation.ispartofpageto1717
dc.relation.ispartofissue10
dc.relation.ispartofjournalACS Infectious Diseases
dc.relation.ispartofvolume5
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchcode3207
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsChemistry, Medicinal
dc.subject.keywordsInfectious Diseases
dc.subject.keywordsPharmacology & Pharmacy
dc.titleEfficient Blocking of Enterovirus 71 Infection by Heparan Sulfate Analogues Acting as Decoy Receptors
dc.typeJournal article
dc.type.descriptionC2 - Articles (Other)
dcterms.bibliographicCitationEarley, DF; Bailly, B; Maggioni, A; Kundur, AR; Thomson, RJ; Chang, C-W; von Itzstein, M, Efficient Blocking of Enterovirus 71 Infection by Heparan Sulfate Analogues Acting as Decoy Receptors, ACS Infectious Diseases, 2019, 5 (10), pp. 1708-1717
dc.date.updated2020-03-19T01:07:21Z
gro.hasfulltextNo Full Text
gro.griffith.authorvon Itzstein, Mark
gro.griffith.authorMaggioni, Andrea
gro.griffith.authorKundur, Avinash R.
gro.griffith.authorThomson, Robin J.


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