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dc.contributor.authorLi, Xu
dc.contributor.authorChu, Min-yi
dc.contributor.authorLv, Qin-yu
dc.contributor.authorHu, Hui-xin
dc.contributor.authorLi, Zhi
dc.contributor.authorYi, Zheng-hui
dc.contributor.authorWang, Jin-hong
dc.contributor.authorZhang, Jian-ye
dc.contributor.authorLui, Simon SY
dc.contributor.authorCheung, Eric FC
dc.contributor.authorShum, David HK
dc.contributor.authorChan, Raymond CK
dc.description.abstractIntroduction: Negative symptoms, particularly amotivation and anhedonia, are important predictors of poor functional outcome in patients with schizophrenia. There has been interest in the efficacy and mechanism of non-pharmacological interventions to alleviate these symptoms. The present study aimed to examine the remediation effect of working memory (WM) training in patients with schizophrenia with prominent negative symptoms. Methods: Thirty-one schizophrenia patients with prominent negative symptoms were recruited and assigned to either a WM training group or a treatment-as-usual (TAU) control group. The WM training group underwent 20 sessions of training using the dual n-back task over one month. A functional neuroimaging paradigm of the Affective Incentive Delay (AID) task was administered before and after the training intervention to evaluate the remediation effect of the intervention. Results: Our results showed that the WM training group demonstrated significant improvement in the WM training task and inattention symptoms. Compared with the TAU group, increased brain activations were observed at the right insula and the right frontal sub-gyral after WM training in the training group. Conclusions: These findings support the efficacy of WM training in ameliorating hedonic dysfunction in schizophrenia patients with prominent negative symptoms.
dc.publisherRoutledge: Taylor & Francis Group
dc.relation.ispartofjournalCognitive Neuropsychiatry
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchPsychology and Cognitive Sciences
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsDual n-back training
dc.subject.keywordshedonic processing
dc.titleThe remediation effects of working memory training in schizophrenia patients with prominent negative symptoms
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationLi, X; Chu, M-Y; Lv, Q-Y; Hu, H-X; Li, Z; Yi, Z-H; Wang, J-H; Zhang, J-Y; Lui, SSY; Cheung, EFC; Shum, DHK; Chan, RCK, The remediation effects of working memory training in schizophrenia patients with prominent negative symptoms, Cognitive Neuropsychiatry, 2019, 24 (6), pp. 434-453
gro.hasfulltextNo Full Text
gro.griffith.authorShum, David
gro.griffith.authorChan, Raymond

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