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dc.contributor.authorTa, Hang T
dc.contributor.authorTruong, Nghia P
dc.contributor.authorWhittaker, Andrew K
dc.contributor.authorDavis, Thomas P
dc.contributor.authorPeter, Karlheinz
dc.date.accessioned2020-03-24T00:44:32Z
dc.date.available2020-03-24T00:44:32Z
dc.date.issued2018
dc.identifier.issn1742-5247
dc.identifier.doi10.1080/17425247.2017.1316262
dc.identifier.urihttp://hdl.handle.net/10072/392564
dc.description.abstractIntroduction: Vascular-targeted drug delivery is a promising approach for the treatment of atherosclerosis, due to the vast involvement of endothelium in the initiation and growth of plaque, a characteristic of atherosclerosis. One of the major challenges in carrier design for targeting cardiovascular diseases (CVD) is that carriers must be able to navigate the circulation system and efficiently marginate to the endothelium in order to interact with the target receptors. Areas covered: This review draws on studies that have focused on the role of particle size, shape, and density (along with flow hemodynamics and hemorheology) on the localization of the particles to activated endothelial cell surfaces and vascular walls under different flow conditions, especially those relevant to atherosclerosis. Expert opinion: Generally, the size, shape, and density of a particle affect its adhesion to vascular walls synergistically, and these three factors should be considered simultaneously when designing an optimal carrier for targeting CVD. Available preliminary data should encourage more studies to be conducted to investigate the use of nano-constructs, characterized by a sub-micrometer size, a non-spherical shape, and a high material density to maximize vascular wall margination and minimize capillary entrapment, as carriers for targeting CVD.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherInforma UK Limited
dc.relation.ispartofpagefrom33
dc.relation.ispartofpageto45
dc.relation.ispartofissue1
dc.relation.ispartofjournalExpert Opinion on Drug Delivery
dc.relation.ispartofvolume15
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode1115
dc.titleThe effects of particle size, shape, density and flow characteristics on particle margination to vascular walls in cardiovascular diseases
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationTa, HT; Truong, NP; Whittaker, AK; Davis, TP; Peter, K, The effects of particle size, shape, density and flow characteristics on particle margination to vascular walls in cardiovascular diseases, Expert Opinion on Drug Delivery, 2018, 15 (1), pp. 33-45
dc.date.updated2020-03-23T05:20:29Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyrightThis is an Author's Accepted Manuscript of an article published in Expert Opinion on Drug Delivery, Volume 15, 2018 - Issue 1, Pages 33-45, 13 Apr 2017, copyright Taylor & Francis, available online at: https://doi.org/10.1080/17425247.2017.1316262
gro.hasfulltextFull Text
gro.griffith.authorTa, Hang


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