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dc.contributor.authorDas, Plabon K
dc.contributor.authorZahan, Tasnim
dc.contributor.authorRakib, Md Abdur
dc.contributor.authorKhanam, Jahan A
dc.contributor.authorPillai, Suja
dc.contributor.authorIslam, Farhadul
dc.date.accessioned2020-03-23T21:46:53Z
dc.date.available2020-03-23T21:46:53Z
dc.date.issued2019
dc.identifier.issn1871-5206
dc.identifier.doi10.2174/1871520619666190704111714
dc.identifier.urihttp://hdl.handle.net/10072/392569
dc.description.abstractBackground: Cancer Stem Cells (CSCs) are the subpopulation of cancer cells which are directly involved in drug resistance, metastases to distant organ and cancer recurrence. Methods: A systematic literature search was conducted through various electronic databases including, Pubmed, Scopus, Google scholar using the keywords "cancer stem cells" and "natural compounds" in the present study. Articles published between 1999 and 2019 were reviewed. All the expositions concerning CSCs associated cancer pathogenesis and therapy resistance, as well as targeting these properties of CSCs by natural compounds were selected for the current study. Results: Natural compounds have always been thought as a rich source of biologically active principles, which target aberrantly activated signaling pathways and other modalities of CSCs, while tethering painful side effects commonly involved in the first-line and second-line chemo-radiotherapies. In this review, we have described the key signaling pathways activated in CSCs to maintain their survival and highlighted how natural compounds interrupt these signaling pathways to minimize therapy resistance, pathogenesis and cancer recurrence properties of CSCs, thereby providing useful strategies to treat cancer or aid in cancer therapy improvement. Like normal stem cells, CSCs rely on different signaling pathways and other properties for their maintenance. Therefore, the success of cancer treatment depends on the development of proper anti-neoplastic drugs capable of intercepting those signaling pathways as well as other properties of CSCs in order to eradicate this evasive subpopulation of cancer cells. Conclusion: Compounds of natural origin might act as an outstanding source to design novel therapies against cancer stem cells.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBentham Science Publishers
dc.relation.ispartofpagefrom1796
dc.relation.ispartofpageto1808
dc.relation.ispartofissue15
dc.relation.ispartofjournalAnti-Cancer Agents in Medicinal Chemistry
dc.relation.ispartofvolume19
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3211
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsOncology
dc.subject.keywordsChemistry, Medicinal
dc.subject.keywordsPharmacology & Pharmacy
dc.titleNatural Compounds Targeting Cancer Stem Cells: A Promising Resource for Chemotherapy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationDas, PK; Zahan, T; Rakib, MA; Khanam, JA; Pillai, S; Islam, F, Natural Compounds Targeting Cancer Stem Cells: A Promising Resource for Chemotherapy, Anti-Cancer Agents in Medicinal Chemistry, 2019, 19 (15), pp. 1796-1808
dcterms.dateAccepted2019-05-20
dc.date.updated2020-03-23T21:37:20Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2019 Bentham Science Publishers. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. The published manuscript is available at EurekaSelect via https://doi.org/10.2174/1871520619666190704111714
gro.hasfulltextFull Text
gro.griffith.authorIslam, Farhad
gro.griffith.authorPillai, Suja
gro.griffith.authorDas, Plabon K.


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