Show simple item record

dc.contributor.authorHo, CSK
dc.contributor.authorLopez, JA
dc.contributor.authorVuckovic, S
dc.contributor.authorPyke, CM
dc.contributor.authorHockey, RL
dc.contributor.authorHart, DNJ
dc.date.accessioned2017-05-03T14:25:41Z
dc.date.available2017-05-03T14:25:41Z
dc.date.issued2001
dc.date.modified2011-06-28T06:45:29Z
dc.identifier.issn0006-4971
dc.identifier.doi10.1182/blood.V98.1.140
dc.identifier.urihttp://hdl.handle.net/10072/39264
dc.description.abstractDendritic cells (DCs) are specialized antigen-presenting cells that have the unique ability to initiate a primary immune response. The effect of physiologic stress on circulating blood DCs has thus far not been studied. In this study, we applied a recently developed method of counting blood DCs to test the hypothesis that significant stress to the body such as surgery and exercise might induce measurable changes in the DC numbers, subsets, phenotype, and function. Twenty-six patients scheduled for elective laparoscopic cholecystectomy, 4 for elective hysterectomy, 56 controls, and 5 volunteers who underwent a stress exercise test were enrolled in the study. Absolute DC counts increased acutely (71.7% 6 11% [SEM], P 5 .0001) in response to the stress of surgery and dropped below preoperative levels (225% 6 14% [SEM], P 5 .05) on days 2-3. The perioperative DC subset balance remained constant. Interestingly, DC counts changed independently ofmonocytecounts. Exercise also induced a rise in DC counts but coincidentally with monocyte counts. Surprisingly, no phenotypic or functional activation of DCs was seen in either stress situations in vivo. DCs are rapidly mobilized into the circulation in response to surgical and exercise stress, which may serve to prepare the host's immune defenses against trauma. The independent regulation of the DC and monocyte counts reinforces the distinction between these 2 cell populations.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Society of Hematology
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom140
dc.relation.ispartofpageto145
dc.relation.ispartofissue1
dc.relation.ispartofjournalBlood
dc.relation.ispartofvolume98
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchCellular immunology
dc.subject.fieldofresearchcode3201
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode320404
dc.titleSurgical and physical stress increase circulating blood dendritic cell counts independently of monocyte counts
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2001
gro.hasfulltextNo Full Text
gro.griffith.authorLopez Ramirez, Alejandro


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record