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dc.contributor.authorDang, HP
dc.contributor.authorHutmacher, DW
dc.contributor.authorTran, PA
dc.date.accessioned2020-03-31T05:02:44Z
dc.date.available2020-03-31T05:02:44Z
dc.date.issued2020
dc.identifier.isbn9789811358586
dc.identifier.issn1680-0737
dc.identifier.doi10.1007/978-981-13-5859-3_25
dc.identifier.urihttp://hdl.handle.net/10072/392818
dc.description.abstractLocal recurrent cancer remains a challenge for breast cancer patients receiving implants after mastectomy or lumpectomy. The use of radiotherapy and/or systemic administration of chemotherapeutic agents post-surgery can be beneficial yet they also kill healthy cells and introduce systemic side effects. In this study, a new method was introduced to utilize 3D printed microporous polycaprolactone (PCL) scaffolds as a multifunctional device—an implant and a drug delivery vehicle for targeted local delivery. Their microporous structure was characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The dependence of release profiles of Doxorubicin (DOX) loaded scaffolds on pH and ionic strength of the environment was demonstrated. Lastly, their chemotherapeutic effect was characterized by in vitro. Overall, the results demonstrated the utility of the microporosity and surface charge of PCL scaffolds to immobilize DOX for local, targeted drug delivery.
dc.description.peerreviewedYes
dc.publisherSpringer
dc.relation.ispartofconferencename7th International Conference on the Development of Biomedical Engineering in Vietnam (BME7)
dc.relation.ispartofconferencetitle7th International Conference on the Development of Biomedical Engineering in Vietnam (BME7)
dc.relation.ispartofdatefrom2018-06-27
dc.relation.ispartofdateto2018-06-29
dc.relation.ispartoflocationHo Chi Minh City, Vietnam
dc.relation.ispartofpagefrom153
dc.relation.ispartofpageto157
dc.relation.ispartofseriesIFMBE Proceedings
dc.relation.ispartofvolume69
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchcode4003
dc.titleThe Use of 3D Printed Microporous-Strut Polycaprolactone Scaffolds for Targeted Local Delivery of Chemotherapeutic Agent for Breast Cancer Application
dc.typeConference output
dc.type.descriptionE1 - Conferences
dcterms.bibliographicCitationDang, HP; Hutmacher, DW; Tran, PA, The Use of 3D Printed Microporous-Strut Polycaprolactone Scaffolds for Targeted Local Delivery of Chemotherapeutic Agent for Breast Cancer Application, 7th International Conference on the Development of Biomedical Engineering in Vietnam (BME7), 2020, 69, pp. 153-157
dc.date.updated2020-03-31T04:59:52Z
gro.hasfulltextNo Full Text
gro.griffith.authorHutmacher, Dietmar W.


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