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dc.contributor.authorLi, Xiangrong
dc.contributor.authorMa, Ruixian
dc.contributor.authorLi, Qian
dc.contributor.authorLi, Shengjun
dc.contributor.authorZhang, Haixia
dc.contributor.authorXie, Jingying
dc.contributor.authorBai, Jialin
dc.contributor.authorIdris, Adi
dc.contributor.authorFeng, Ruofei
dc.date.accessioned2020-04-01T02:09:33Z
dc.date.available2020-04-01T02:09:33Z
dc.date.issued2019
dc.identifier.issn1664-302X
dc.identifier.doi10.3389/fmicb.2019.02680
dc.identifier.urihttp://hdl.handle.net/10072/392845
dc.description.abstractEncephalomyocarditis virus (EMCV) causes encephalitis, myocarditis, neuropathy, reproductive disorders, and diabetes in animals. EMCV is known to induce cell autophagy; however, the molecular mechanisms underlying this remain unclear. Here, we show that the type III-transmembrane protein, transmembrane protein 39A (TMEM39A), plays a critical role in EMCV replication. We showed that EMCV GS01 strain infection upregulated TMEM39A expression. Importantly, EMCV induced autophagy in a range of host cells. The autophagy chemical inhibitor, 3-MA, inhibited EMCV replication and reduced TMEM39A expression. This is the first study demonstrating TMEM39A promoting the replication of EMCV via autophagy. Overall, we show that TMEM39A plays a positive regulatory role in EMCV proliferation and that TMEM39A expression is dependent on the autophagy pathway.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherFrontiers Media
dc.relation.ispartofjournalFrontiers in Microbiology
dc.relation.ispartofvolume10
dc.subject.fieldofresearchEnvironmental Science and Management
dc.subject.fieldofresearchSoil Sciences
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchcode0502
dc.subject.fieldofresearchcode0503
dc.subject.fieldofresearchcode0605
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordstransmembrane protein 39A
dc.subject.keywordsencephalomyocarditis virus
dc.titleTransmembrane Protein 39A Promotes the Replication of Encephalomyocarditis Virus via Autophagy Pathway
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationLi, X; Ma, R; Li, Q; Li, S; Zhang, H; Xie, J; Bai, J; Idris, A; Feng, R, Transmembrane Protein 39A Promotes the Replication of Encephalomyocarditis Virus via Autophagy Pathway, Frontiers in Microbiology, 2019, 10
dcterms.dateAccepted2019-11-05
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-04-01T02:06:24Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2019 Li, Ma, Li, Li, Zhang, Xie, Bai, Idris and Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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gro.griffith.authorIdris, Adi


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