dc.contributor.author | B. Rosen, David | |
dc.contributor.author | Bettadapura, Jayaram | |
dc.contributor.author | Alsharifi, Mohammed | |
dc.contributor.author | A. Mathew, Porunelloor | |
dc.contributor.author | S. Warren, Hilary | |
dc.contributor.author | L. Lanier, Lewis | |
dc.date.accessioned | 2017-05-03T16:00:59Z | |
dc.date.available | 2017-05-03T16:00:59Z | |
dc.date.issued | 2005 | |
dc.date.modified | 2011-06-29T08:09:26Z | |
dc.identifier.issn | 00221767 | |
dc.identifier.uri | http://hdl.handle.net/10072/39290 | |
dc.description.abstract | Increasingly, roles are emerging for C-type lectin receptors in immune regulation. One receptor whose function has remained largely enigmatic is human NKR-P1A (CD161), present on NK cells and subsets of T cells. In this study, we demonstrate that the lectin-like transcript-1 (LLT1) is a physiologic ligand for NKR-P1A. LLT1-containing liposomes bind to NKR-P1A+ cells, and binding is inhibited by anti-NKR-P1A mAb. Additionally, LLT1 activates NFAT-GFP reporter cells expressing a CD3?-NKR-P1A chimeric receptor; reciprocally, reporter cells with a CD3?-LLT1 chimeric receptor are stimulated by NKR-P1A. Moreover, LLT1 on target cells can inhibit NK cytotoxicity via interactions with NKR-P1A. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | The American Association of Immunologists | |
dc.publisher.place | USA | |
dc.publisher.uri | http://www.ncbi.nlm.nih.gov/pubmed/16339513 | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 7796 | |
dc.relation.ispartofpageto | 7799 | |
dc.relation.ispartofjournal | Journal of Immunology | |
dc.relation.ispartofvolume | 175 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Innate Immunity | |
dc.subject.fieldofresearch | Immunology | |
dc.subject.fieldofresearchcode | 110707 | |
dc.subject.fieldofresearchcode | 1107 | |
dc.title | Cutting Edge: Lectin-Like Transcript-1 Is a Ligand for the Inhibitory Human NKR-P1A Receptor | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2005 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Bettadapura, Jayaram | |