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dc.contributor.authorHe, WQ
dc.contributor.authorShakri, AR
dc.contributor.authorBhardwaj, R
dc.contributor.authorFrança, CT
dc.contributor.authorStanisicid, DI
dc.contributor.authorHealer, J
dc.contributor.authorKiniboro, B
dc.contributor.authorRobinson, LJ
dc.contributor.authorGuillotte-Blisnick, M
dc.contributor.authorHuon, C
dc.contributor.authorSiba, P
dc.contributor.authorCowman, A
dc.contributor.authorKing, CL
dc.contributor.authorTham, WH
dc.contributor.authorChitnis, CE
dc.contributor.authorMueller, I
dc.date.accessioned2020-04-02T01:29:13Z
dc.date.available2020-04-02T01:29:13Z
dc.date.issued2019
dc.identifier.issn1935-2727
dc.identifier.doi10.1371/journal.pntd.0006987
dc.identifier.urihttp://hdl.handle.net/10072/392911
dc.description.abstractBackground: The Plasmodium vivax Duffy Binding Protein (PvDBP) is a key target of naturally acquired immunity. However, region II of PvDBP, which contains the receptor-binding site, is highly polymorphic. The natural acquisition of antibodies to different variants of PvDBP region II (PvDBPII), including the AH, O, P and Sal1 alleles, the central region III-V (PvDBPIII-V), and P. vivax Erythrocyte Binding Protein region II (PvEBPII) and their associations with risk of clinical P. vivax malaria are not well understood. Methodology: Total IgG and IgG subclasses 1, 2, and 3 that recognize four alleles of PvDBPII (AH, O, P, and Sal1), PvDBPIII-V and PvEBPII were measured in samples collected from a cohort of 1 to 3 year old Papua New Guinean (PNG) children living in a highly endemic area of PNG. The levels of binding inhibitory antibodies (BIAbs) to PvDBPII (AH, O, and Sal1) were also tested in a subset of children. The association of presence of IgG with age, cumulative exposure (measured as the product of age and malaria infections during follow-up) and prospective risk of clinical malaria were evaluated. Results: The increase in antigen-specific total IgG, IgG1, and IgG3 with age and cumulative exposure was only observed for PvDBPII AH and PvEBPII. High levels of total IgG and predominant subclass IgG3 specific for PvDBPII AH were associated with decreased incidence of clinical P. vivax episodes (aIRR = 0.56–0.68, P≤0.001–0.021). High levels of total IgG and IgG1 to PvEBPII correlated strongly with protection against clinical vivax malaria compared with IgGs against all PvDBPII variants (aIRR = 0.38, P<0.001). Antibodies to PvDBPII AH and PvEBPII showed evidence of an additive effect, with a joint protective association of 70%. Conclusion: Antibodies to the key parasite invasion ligands PvDBPII and PvEBPII are good correlates of protection against P. vivax malaria in PNG. This further strengthens the rationale for inclusion of PvDBPII in a recombinant subunit vaccine for P. vivax malaria and highlights the need for further functional studies to determine the potential of PvEBPII as a component of a subunit vaccine for P. vivax malaria.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherPublic Library of Science (PLoS)
dc.relation.ispartofissue2
dc.relation.ispartofjournalPLoS Neglected Tropical Diseases
dc.relation.ispartofvolume13
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.titleAntibody responses to Plasmodium vivax Duffy binding and Erythrocyte binding proteins predict risk of infection and are associated with protection from clinical Malaria
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationHe, WQ; Shakri, AR; Bhardwaj, R; França, CT; Stanisicid, DI; Healer, J; Kiniboro, B; Robinson, LJ; Guillotte-Blisnick, M; Huon, C; Siba, P; Cowman, A; King, CL; Tham, WH; Chitnis, CE; Mueller, I, Antibody responses to Plasmodium vivax Duffy binding and Erythrocyte binding proteins predict risk of infection and are associated with protection from clinical Malaria, PLoS Neglected Tropical Diseases, 2019, 13 (2), pp. e0006987-
dcterms.dateAccepted2018-11-12
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-04-02T01:23:49Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2019 He et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
gro.hasfulltextFull Text
gro.griffith.authorStanisic, Danielle


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