Insulin resistance in a cohort of 5-15 year old children in urban Sri Lanka

Abstract

Background: South Asian populations develop insulin resistance from a young age. Poor intrauterine growth and increased rates of post natal growth predisposes to develop insulin resistance later in life. This study identifies insulin resistance and relation to birth weight among a group of 5-15 year old children of urban Sri Lanka. Methods: A cross sectional descriptive study, using two-stage probability proportionate cluster sampling technique. After a 12 h overnight fast, blood was drawn for fasting blood glucose and insulin. OGTT was performed with 2 h random blood glucose. Basic anthropometry was assessed and insulin resistance measured by HOMA-IR. Results: Of 309 children (boys 133) 13 (4.2%) were obese and 35 (11.3%) were overweight. Eight had impaired glucose homeostasis but no diabetes mellitus. The mean (SD) fasting insulin was 37.8 (37.9) and 32.5 (40.4) pmol/L in girls and boys respectively. 2 h post glucose insulin in girls and boys were 258 (324) and 152 (168) pmol/L respectively. The mean HOMA-IR was 1.1 (1.1) and 0.94 (1.2) for girls and boys respectively. The 4th quartile value of HOMA-IR for the whole population was 1.2 (95% CI 1.1, 1.3) and in obese children 2.26 (95% CI 2.0, 3.1). Fasting and 2 h insulin and HOMA-IR was not affected by birth weight but showed significant difference when compared across present BMI tertile with significantly high values in the highest tertile. Conclusion: Although many children were able to control glucose within normal limits, evidence of early development of insulin resistance was seen. Children born small but became obese, had the highest risk of developing insulin resistance.