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dc.contributor.authorHoseini-Yazdi, Hosein
dc.contributor.authorVincent, Stephen J
dc.contributor.authorCollins, Michael J
dc.contributor.authorRead, Scott A
dc.contributor.authorAlonso-Caneiro, David
dc.date.accessioned2020-04-16T03:39:27Z
dc.date.available2020-04-16T03:39:27Z
dc.date.issued2019
dc.identifier.issn2045-2322
dc.identifier.doi10.1038/s41598-019-39653-w
dc.identifier.urihttp://hdl.handle.net/10072/393120
dc.description.abstractThere is a paucity of knowledge regarding the normal in-vivo thickness of the choroid beyond the macula (~17°). In this study, the choroidal thickness of 27 healthy young adults was examined across the macular (the central 5 mm including the fovea, parafovea, and perifovea) and extra-macular (a 5–14 mm annulus including the near-periphery and periphery) regions using wide-field optical coherence tomography, and compared between emmetropes (n = 14) and myopes (n = 13). The choroid progressively thinned beyond the parafovea (350 ± 86 µm) towards the periphery (264 ± 44 µm), and was thickest superiorly (355 ± 76 µm) and thinnest nasally (290 ± 79 µm). Choroidal thickness also varied with refractive error; myopes exhibited a thinner choroid than emmetropes in the macular region (311 ± 88 vs. 383 ± 66 µm), however, this difference diminished towards the periphery (251 ± 48 vs. 277 ± 37 µm). Meridional variations in choroidal thickness were not different between myopes and emmetropes. In conclusion, the choroid was thickest within the perifovea; thinned substantially towards the periphery, and exhibited the minimum and maximum peripheral thinning superiorly and nasally across a 55° region respectively. Choroidal thinning associated with myopia was more pronounced in the macular than extra-macular regions.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofissue1
dc.relation.ispartofjournalScientific Reports
dc.relation.ispartofvolume9
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchOther Physical Sciences
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode0299
dc.subject.keywordsScience & Technology
dc.subject.keywordsMultidisciplinary Sciences
dc.subject.keywordsScience & Technology - Other Topics
dc.subject.keywordsOPTICAL COHERENCE TOMOGRAPHY
dc.subject.keywordsCHILDREN AGED 6
dc.titleWide-field choroidal thickness in myopes and emmetropes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationHoseini-Yazdi, H; Vincent, SJ; Collins, MJ; Read, SA; Alonso-Caneiro, D, Wide-field choroidal thickness in myopes and emmetropes, Scientific Reports, 2019, 9 (1)
dcterms.dateAccepted2019-01-23
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-04-16T03:37:05Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
gro.hasfulltextFull Text
gro.griffith.authorAlonso-Caneiro, David


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