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  • Cost-effectiveness analysis of germline brca mutation testing and olaparib treatment in metastatic breast cancer: An evaluation of codependent technologies

    Author(s)
    Tuffaha, H
    Scuffham, P
    Griffith University Author(s)
    Scuffham, Paul A.
    Year published
    2019
    Metadata
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    Abstract
    Genetic testing for a germline BRCA mutation in women with HER2-negative metastatic breast cancer (MBC) can guide targeted treatment with PARP inhibitors (e.g. olaparib) and inform cancer prevention strategies (e.g., risk-reducing surgery) for family members of women who test positive. Unlike BRCA testing in localised breast cancer, the cost-effectiveness of genetic testing in MBC is unknown. This study aimed to evaluate the cost-effectiveness of BRCA testing in women with MBC to guide olaparib treatment.Genetic testing for a germline BRCA mutation in women with HER2-negative metastatic breast cancer (MBC) can guide targeted treatment with PARP inhibitors (e.g. olaparib) and inform cancer prevention strategies (e.g., risk-reducing surgery) for family members of women who test positive. Unlike BRCA testing in localised breast cancer, the cost-effectiveness of genetic testing in MBC is unknown. This study aimed to evaluate the cost-effectiveness of BRCA testing in women with MBC to guide olaparib treatment.
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    Conference Title
    VALUE IN HEALTH
    Volume
    22
    Issue
    Supplement 3
    DOI
    https://doi.org/10.1016/j.jval.2019.09.292
    Funder(s)
    NHMRC
    Grant identifier(s)
    APP1121232
    Subject
    Applied economics
    Social Sciences
    Science & Technology
    Life Sciences & Biomedicine
    Economics
    Health Care Sciences & Services
    Publication URI
    http://hdl.handle.net/10072/393168
    Collection
    • Conference outputs

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