Manipulation and sensing of microparticles using dielectric properties
The ability of electrokinetics to manipulate biological microparticles, such as cells and bacteria, has great applications in Lab-on-a-chip devices, and micro-total analysis systems (mTAS). In these methods, non-uniform AC electric fields interact with the dielectric properties of suspended biological microparticles to induce forces and torques on the particles, in order to manipulate them. This is usually done using devices which are planar microelectrode arrays patterned on glass substrates. These devices usually exploit the fact that biological microparticles are dielectrically heterogeneous structures, and that each different type of biological particle has a distinct dielectric frequency response signature. This enables discrimination and selectivity of cells when manipulating electrokinetically. Electrokinetics in the form of Dielectrophoresis (DEP) and Travelling-Wave Dielectrophoresis (TWD) are used to induce rectilinear motion on suspended microparticles, whilst electrorotation is used to induce torques. This paper presents a device for manipulating biological microparticles using electrokinetics. The device consists of planar metal electrode arrays patterned on glass. The device exploits the dielectric frequency response of the microparticles for manipulation as well as sensing.
Biomedical Applications of Micro- and Nanoengineering II