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dc.contributor.authorRudrawar, Santosh
dc.contributor.authorRyan, Philip
dc.date.accessioned2020-04-30T02:24:12Z
dc.date.available2020-04-30T02:24:12Z
dc.date.issued2019
dc.identifier.issn0022-2623
dc.identifier.doi10.1021/acs.jmedchem.9b01668
dc.identifier.urihttp://hdl.handle.net/10072/393281
dc.description.abstractPathological hyperphosphorylation of tau and subsequent aggregation to form neurofibrillary tangles (NFTs) is closely related to progression of neurodegenerative diseases such as Alzheimer’s disease (AD) and progressive supranuclear palsy. A recent study showed that MK-8719 (6) is a selective and potent small molecule inhibitor of human O-GlcNAcase (hOGA). The pharmacological inhibition of OGA, the sole enzyme involved in removal of a sugar moiety (O-GlcNAc residue) from tau, increases global O-GlcNAc levels within the brain and reduces tau phosphorylation. The OGA inhibitor slows neurodegeneration and improves cognitive function in AD and related tauopathies. Here, we discuss the findings of that study and the development of OGA inhibitors as novel therapeutic strategy for treatment of age-related memory impairment in neurodegenerative diseases.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.ispartofpagefrom10059
dc.relation.ispartofpageto10061
dc.relation.ispartofissue22
dc.relation.ispartofjournalJournal of Medicinal Chemistry
dc.relation.ispartofvolume62
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3405
dc.subject.fieldofresearchcode3214
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsChemistry, Medicinal
dc.subject.keywordsPharmacology & Pharmacy
dc.subject.keywordsINHIBITOR
dc.titleSugar Kick Prevents Memory Impairment
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationRudrawar, S; Ryan, P, Sugar Kick Prevents Memory Impairment, Journal of Medicinal Chemistry, 2019, 62 (22), pp. 10059-10061
dc.date.updated2020-04-20T23:31:14Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyrightThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Medicinal Chemistry, copyright 2019 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jmedchem.9b01668
gro.hasfulltextFull Text
gro.griffith.authorRudrawar, Santosh


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