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  • Anticancer potential of Michelia champaca Linn. bark against Ehrlich ascites carcinoma (EAC) cells in Swiss albino mice

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    Accepted Manuscript (AM)
    Author(s)
    Yesmin, Ruksana
    Das, Plabon Kumar
    Belal, Hazrat
    Aktar, Suraiya
    Siddika, Ayesha
    Asha, Saharia Yeasmin
    Habib, Farjana
    Rakib, Md Abdur
    Islam, Farhadul
    Griffith University Author(s)
    Islam, Farhad
    Year published
    2019
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    Abstract
    Background: Adverse side effects of currently available therapies against cancer, leads scientists to find effective compounds from natural sources. Objective: In the present study, stem-bark of Mycelia champaca is subjected to evaluate its anti-proliferative effect against Ehrlich ascites carcinoma (EAC) cells. To date, anti-proliferative effects of M. champaca bark extract against EAC cell line has not been reported elsewhere. Therefore, we intended to investigate the anti-proliferative potential of M. champaca bark extract against EAC cells in vivo. Methods: In vivo anticancer activity was evaluated against EAC cells ...
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    Background: Adverse side effects of currently available therapies against cancer, leads scientists to find effective compounds from natural sources. Objective: In the present study, stem-bark of Mycelia champaca is subjected to evaluate its anti-proliferative effect against Ehrlich ascites carcinoma (EAC) cells. To date, anti-proliferative effects of M. champaca bark extract against EAC cell line has not been reported elsewhere. Therefore, we intended to investigate the anti-proliferative potential of M. champaca bark extract against EAC cells in vivo. Methods: In vivo anticancer activity was evaluated against EAC cells bearing Swiss albino mice by monitoring parameters such as tumor cell proliferation, tumor weight measurement, and survival time etc. The mechanism of EAC killing was examined by observation of cell morphology and analysis the expression of certain cancer related genes. In vitro antioxidant potentiality was determined in terms of several common antioxidant assays. In addition, total phenolic and flavonoids contents were measured to insure the presence of phytochemicals. Results: M. champaca bark extract showed strong antioxidant activities which were found to be strongly correlated (P<0.001) with phenolics and flavonoids contents. Furthermore, it was found that bark extract decreased tumor cell proliferation (77.46%; P<0.01), tumor weight (42.13%; P<0.001) and increased life span of tumor bearing mice (71.97%; P<0.01) at the dose of 250mg/kg (intraperitoneal; i.p.). M. champaca bark also altered the depleted hematological parameters such as red blood cell, white blood cell, hemoglobin (Hb%) towards normal in tumor bearing mice. In addition, upregulation ofp53, Bax and downregulation Bcl-2 followed by treatmentindicated M. champacabark could induce apoptosis of EAC cells. Conclusion: These results indicated that MEMCB possesses significant cytotoxic activities against EAC cells and has a strong in vitro antioxidant capacity. Therefore, bark of M. champaca could be considered as a potential resource of anti-cancer agents, which might be used to formulate effective anticancer drugs.
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    Journal Title
    The Natural Products Journal
    DOI
    https://doi.org/10.2174/2210315509666191120105647
    Copyright Statement
    © 2019 Bentham Science Publishers. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. The published manuscript is available at EurekaSelect via DOI.
    Note
    This publication has been entered into Griffith Research Online as an Advanced Online Version.
    Subject
    Biological sciences
    Publication URI
    http://hdl.handle.net/10072/393309
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    • Journal articles

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