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dc.contributor.authorYesmin, Ruksana
dc.contributor.authorDas, Plabon Kumar
dc.contributor.authorBelal, Hazrat
dc.contributor.authorAktar, Suraiya
dc.contributor.authorSiddika, Ayesha
dc.contributor.authorAsha, Saharia Yeasmin
dc.contributor.authorHabib, Farjana
dc.contributor.authorRakib, Md Abdur
dc.contributor.authorIslam, Farhadul
dc.date.accessioned2020-04-30T00:08:49Z
dc.date.available2020-04-30T00:08:49Z
dc.date.issued2019
dc.identifier.issn2210-3155
dc.identifier.doi10.2174/2210315509666191120105647
dc.identifier.urihttp://hdl.handle.net/10072/393309
dc.description.abstractBackground: Adverse side effects of currently available therapies against cancer, leads scientists to find effective compounds from natural sources. Objective: In the present study, stem-bark of Mycelia champaca is subjected to evaluate its anti-proliferative effect against Ehrlich ascites carcinoma (EAC) cells. To date, anti-proliferative effects of M. champaca bark extract against EAC cell line has not been reported elsewhere. Therefore, we intended to investigate the anti-proliferative potential of M. champaca bark extract against EAC cells in vivo. Methods: In vivo anticancer activity was evaluated against EAC cells bearing Swiss albino mice by monitoring parameters such as tumor cell proliferation, tumor weight measurement, and survival time etc. The mechanism of EAC killing was examined by observation of cell morphology and analysis the expression of certain cancer related genes. In vitro antioxidant potentiality was determined in terms of several common antioxidant assays. In addition, total phenolic and flavonoids contents were measured to insure the presence of phytochemicals. Results: M. champaca bark extract showed strong antioxidant activities which were found to be strongly correlated (P<0.001) with phenolics and flavonoids contents. Furthermore, it was found that bark extract decreased tumor cell proliferation (77.46%; P<0.01), tumor weight (42.13%; P<0.001) and increased life span of tumor bearing mice (71.97%; P<0.01) at the dose of 250mg/kg (intraperitoneal; i.p.). M. champaca bark also altered the depleted hematological parameters such as red blood cell, white blood cell, hemoglobin (Hb%) towards normal in tumor bearing mice. In addition, upregulation ofp53, Bax and downregulation Bcl-2 followed by treatmentindicated M. champacabark could induce apoptosis of EAC cells. Conclusion: These results indicated that MEMCB possesses significant cytotoxic activities against EAC cells and has a strong in vitro antioxidant capacity. Therefore, bark of M. champaca could be considered as a potential resource of anti-cancer agents, which might be used to formulate effective anticancer drugs.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBentham Science Publishers Ltd.
dc.relation.ispartofjournalThe Natural Products Journal
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchcode06
dc.titleAnticancer potential of Michelia champaca Linn. bark against Ehrlich ascites carcinoma (EAC) cells in Swiss albino mice
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationYesmin, R; Das, PK; Belal, H; Aktar, S; Siddika, A; Asha, SY; Habib, F; Rakib, MA; Islam, F, Anticancer potential of Michelia champaca Linn. bark against Ehrlich ascites carcinoma (EAC) cells in Swiss albino mice, The Natural Products Journal, 2019
dc.date.updated2020-04-21T02:35:40Z
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.rights.copyright© 2019 Bentham Science Publishers. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. The published manuscript is available at EurekaSelect via DOI.
gro.hasfulltextFull Text
gro.griffith.authorIslam, Farhad
gro.griffith.authorDas, Plabon K.


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